ESPE Abstracts (2014) 82 P-D-1-2-113

Prenatal Maternal Weight and Weight Status and Lipid Profile of the Offspring

Isolina Riaño-Galana, Cristina Rodriguez-Dehlia, Ines Olaya Velázqueza, Ana Fernández-Somoanob, Damaskini Valvic, Marisa Rebagliatod, Jesus Ibarluzeae & Adonina Tardonb


aHospital San Agustín Pediatria, Aviles, Spain; bCIBERESP and Oviedo University, Preventive Medicine, Oviedo, Spain; cCIBERESP and Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; dCIBERESP and Unit of Environment and Health, Centre for Public Health Research (CSISP/FISABIO), Valencia, Spain; eCIBERESP and BioDonostia Health Research Institute, Donostia, Spain


Background: Childhood obesity is a serious public health concern. To identify risk for obesity in early childhood is important.

Objective: To analyse association of pre-pregnancy maternal weight with BMI and metabolic profile at 4 years.

Methods: 2604 pregnant mothers and 1960 children from the Spanish population-based cohort study Environment and Childhood (INfancia y Medio Ambiente) Project (INMA). Research protocol was approved by the Ethics Committee. We analysed maternal BMI, gestational weight gain (GWG), BMI at 4 years and prevalence of overweight (OW) and obesity (OB) according to IOTF. Lipid profile was determined in a subgroup of children.

Results: 4.6% mothers were underweight (BMI <18.5 kg/m2), 68.8% normal (BMI 18.5–24.9 kg/m2), 18.7% had OW (BMI 25–29.9 kg/m2) and 7.9% OB (BMI ≥30 kg/m2). GWG was as recommended in 37.9% pregnant mothers, low in 24.2% and high in 37.9%. 20.2% children had OW or OB at 4 years. There are positive association between pre-pregnancy BMI and BMI at 4 years (P-trend <0.001). Maternal pre-pregnancy OW/OB increases the risk of child OW/OB by 1.3 (95% CI: 1.2–1.4). Table 1 shows lipid profile at 4 years (mean (S.D.)).

Table 1.
Normal weight (n=413)Overweight (n=70)Obese (n=35)P (trend)
Total cholesterol (mg/dl)163.9 (27.2)168.1 (24.9)171.9 (24.8)0.050
C-HDL (mg/dl)54.5 (12.2)51.4 (11.2)51.9 (9.2)0.042
Triglycerides (mg/dl)78.9 (40.4)85.8 (42.2)98.5 (52.2)0.005

Conclusions: High prevalence of OW/OB maternal and at 4 years was detected. Correlation between them was found. An adverse metabolic profile is associated with overweight and obesity in 4 years-old children. Childhood obesity prevention must be started from pregnancy and infancy. Global cardiovascular risk prevention program focused on obesity prevention must be applied early in life. Table 1

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