Background: Childhood obesity is a serious public health concern. To identify risk for obesity in early childhood is important.
Objective: To analyse association of pre-pregnancy maternal weight with BMI and metabolic profile at 4 years.
Methods: 2604 pregnant mothers and 1960 children from the Spanish population-based cohort study Environment and Childhood (INfancia y Medio Ambiente) Project (INMA). Research protocol was approved by the Ethics Committee. We analysed maternal BMI, gestational weight gain (GWG), BMI at 4 years and prevalence of overweight (OW) and obesity (OB) according to IOTF. Lipid profile was determined in a subgroup of children.
Results: 4.6% mothers were underweight (BMI <18.5 kg/m2), 68.8% normal (BMI 18.524.9 kg/m2), 18.7% had OW (BMI 2529.9 kg/m2) and 7.9% OB (BMI ≥30 kg/m2). GWG was as recommended in 37.9% pregnant mothers, low in 24.2% and high in 37.9%. 20.2% children had OW or OB at 4 years. There are positive association between pre-pregnancy BMI and BMI at 4 years (P-trend <0.001). Maternal pre-pregnancy OW/OB increases the risk of child OW/OB by 1.3 (95% CI: 1.21.4). Table 1 shows lipid profile at 4 years (mean (S.D.)).
|Normal weight (n=413)||Overweight (n=70)||Obese (n=35)||P (trend)|
|Total cholesterol (mg/dl)||163.9 (27.2)||168.1 (24.9)||171.9 (24.8)||0.050|
|C-HDL (mg/dl)||54.5 (12.2)||51.4 (11.2)||51.9 (9.2)||0.042|
|Triglycerides (mg/dl)||78.9 (40.4)||85.8 (42.2)||98.5 (52.2)||0.005|
Conclusions: High prevalence of OW/OB maternal and at 4 years was detected. Correlation between them was found. An adverse metabolic profile is associated with overweight and obesity in 4 years-old children. Childhood obesity prevention must be started from pregnancy and infancy. Global cardiovascular risk prevention program focused on obesity prevention must be applied early in life. Table 1
20 - 22 Sep 2014
European Society for Paediatric Endocrinology