Background: Polycystic ovary syndrome (PCOS) is a common endocrinological disorder of unclear etiopathogenesis characterized by hormonal and reproductive abnormalities which may coexist with metabolic disturbances.
Objective and hypotheses: To investigate the role of endocrine disruptor bisphenol A (BPA) in etiopathogenesis of PCOS in adolescent girls. Additionally, we wished to investigate the relationship between BPA and metabolic parameters, insulin resistance and obesity in this population.
Method: A total of 112 PCOS patients (52 obese and 60 lean) aged 1319 years and 61 age-matched healthy controls (35 obese and 26 lean) were included in the study. Anthropometric measurements, hormonal and metabolic parameters and serum BPA levels were evaluated in all participants. BPA was measured by HPLC. An oral glucose tolerance test was performed in the groups of PCOS and obese controls. Insulin resistance was determined using HOMA-IR, QUICK1, fasting glucose/insulin ratio, Matsuda index, and total insulin levels during OGTT.
Results: Adolescents with PCOS had markedly increased serum BPA levels (1.1±0.4; 0.8±0.3 ng/ml; P=0.001). BPA was significantly correlated with gynaecological age, total and free testosterone, DHEA-S, and FerrimanGallwey score (r=0.29; r=0.52; r=0.44; r=0.37; and r=0.43 respectively). There was no statistically significant difference between PCOS and control groups regarding serum glucose, lipids, transaminases, insulin, HOMA-IR, QUICK1, Matsuda index, and FGIR.
Conclusion: Adolescent girls with PCOS have higher serum BPA levels than controls. Moreover, BPA concentrations are significantly correlated with androgen levels leading us to consider that BPA might have a potential role in etiopathogenesis of PCOS in adolescents.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology