ESPE Abstracts (2014) 82 P-D-3-3-652

Preservation of Ovarian Function in Young Females Cancer Survivors with Risk of Ovarian Failure

Maria Chueca, Sara Berrade, Isabel San Miguel, Mirentxu Oyarzábal, Maria Sagaseta de Ilurdoz, Teodoro Dura & Javier Molina


S° Pediatria, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain


Background: Ovarian function in young females with cancer can be damaged due to chemo-radiotherapy. One option to preserve fertility in these patients is the cryopreservation of ovarian tissue, but this is still experimental.

Objective and hypotheses: Evaluate our experience with cryopreservation (indications, complications, and reimplantation). Through surveys, understand patient perspectives.

Method: A total of 63 women were diagnosed with cancer (2006–2013). 25 were peripuberal (>9 years old). Nine presented with high risk of ovarian failure (eight Hodgkin’s disease and one metastatic rhabdomyosarcoma but was not a candidate due to her advanced condition); cryopreservation was offered to these eight patients including one with a medium risk for osteogenic sarcoma, and all accepted. Patient opinion of the procedure is evaluated, and gonadal function is analyzed through hormonal analysis.

Results: Characteristics of the nine patients in which cryopreservation was conducted: age at diagnosis 11–15 years old, current age 14–23 years old. FSH levels were from to 2.7 to >200 mU/ml and 17β-estradiol 5–77 pg/ml. Inhibin B ranged from 77 to <10 pg/ml, and AMH 8.1 to <0.1 ng/ml. One patient had ovarian failure, FSH >200, estradiol 5, inhibin B 4 and is under replacement therapy. The cryopreservation was conducted at a specialty clinic via laparoscopy with general anestesia. In 1–3 days, without delay of oncological treatment, they returned to our center. Patients positively reviewed the procedure conducted and none of them had undergone reimplantation at the time of the survey.

Conclusion: Given the potential risk of oncological treatment, the cryopreservation of ovarian tissue in high-risk adolescents is an option to consider. The procedure is minimally invasive and well-received by the patients. The procedure should be considered on a case-by-case basis, and patients should be informed of the risks/benefits associated with the procedure.

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