ESPE Abstracts (2014) 82 P-D-3-3-842

Pubertal Development of Isolated GH Deficient Patients

Soumeya Fedalaa, Mahdi el Mahdi Haddamb & Farida Chentlia


aBab El Oued Hospital, Algiers, Algeria; bBologhine Hospital, Algiers, Algeria


Background: Hormone deficiency no or late treated causes delayed puberty and reduced final height.

Objective and hypotheses: Assess the progress of puberty in isolated GH deficient (GHD) patients.

Method: 34 patients with GHD in puberty were followed in endocrinology. The average age at diagnosis of GH deficiency was 8±2.4 (7–19) in girls and 9±1.2 (8–18) in boys. The majority of patients received an irregular GH treatment. The assessment of puberty studied: the Age at puberty and its progress and age ménarchie.

Results: Delayed puberty is reported in all patients. Age of pubertal development was 16.44±2.36 years for boys and 13.88±2.96 years for girls. The mean age of 15.46±ménarche is delayed 2.00. The course of puberty was normal except for five patients precociously treated with GHR (average 2 years)

Conclusion: Early treatment with GHR allows normal pubertal development by inducing local production of IGF1 in the gonads by promoting local production of sex steroid and follicular development. Whether puberty occurs normally in patients treated precociously, an advance of puberty and reduced the duration of the course of puberty may even. It is linked to the action of GH on bone maturation.

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