ESPE Abstracts (2014) 82 P-D-3-3-940

Inhibin B in the Boys with Constitutional Delay of Puberty: Relationship with Gonadotropins, Testosterone, and Anti-Mullerian Factor

Oleg Latyshev, Elena Kiseleva, Goar Okminyan & Lubov Samsonova


Russian Medical Academy of Postgraduated Education, Moscow, Russia


Objective: The aim of this study were to investigate the level of inhibin B and its relationship with testosterone, anti-Müllerian factor, basal, and GnRH-stimulated gonadotropin hormones (LH and FSH) concentration in boys with constitutional delay of puberty.

Material and methods: In the study were included 15 boys (mean age 14.5±1.6 years) in Tanner stages 1–2. The investigation consists of genital examination with prader orchidometer, definition pubertal stage, ultrasound examination of the testis, analyzing basal level testosterone, LH, SSH; and GnRH agonist test.

Results: In the boys with constitutional delay of puberty the mean level of inhibin B was 155.6±69.72 pg/ml; LH 1.23±0.77 mIU/ml; FSH 2.36±2.0 mIU/ml; and testosterone 5.28±5.9 nmol/l. Inhibin B correlated positively with GnRH-stimulated FSH concentration (P=0.05) and correlated negatively with anti-Müllerian factor (P=0.017). Inhibin B did not correlated with basal level FSH, LH, testosterone, and stimulated LH.

Conclusion: It has been revealed positively relationship between inhibin B and stimulated FSH and negatively correlation with anti-Müllerian factor in the boys with constitutional delay of puberty.

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