Background: A greater number of male (M) vs female (F) patients are diagnosed with GH deficiency (GHD). M have larger birth weight (BW), length and head circumference (HC) compared to F; these characteristics could contribute to subtle cephalo-pelvic disproportion and mild head trauma possibly contributing to idiopathic GHD (IGHD) and multiple pituitary hormone deficiencies (MPHD).
Objective: To determine birth characteristics including mode of delivery and MRI abnormalities that could influence the M to F preponderance in IGHD and in MPHD.
Method: Patients with IGHD (n=14853) and MPHD (n=5218) with a stimulated peak GH<7 μg/l registered in Pfizer International Growth Database were studied. Wilcoxon rank sum test and ANOVA were used for analyses, with P-value<0.01 considered significant.
Results: Data are shown as means; *=P<0.001 in M vs F.
|IGHD (GH <7 μg/l)||MPHD|
|Max GH (μg/l)||4.3||4.3||4.3||4.5|
|Normal delivery (%)||77.8||78.7||68.5||74.8*|
|+MRI normal (%)||84.0||82.7||69.0||69.7|
|+MRI normal (%)||72.5||83.9||36.6||40.7|
Conclusion: Breech delivery was higher in MPHD compared to IGHD and higher in males with MPHD. More MRI abnormalities were reported in MPHD patients without gender difference. Further evaluation of the relationship between gender and diagnosis of pituitary hormone deficiencies is warranted.
Conflict of Interest: C Camacho-Hubner and A Lindberg are full time employees of Pfizer Inc.
Funding: Pfizer International Growth Database is a static database sponsor by Pfizer Inc.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology