ESPE2015 Poster Category 3 GH & IGF (68 abstracts)
Decrease of Small Dense LDL and Lipoprotein-Associated Phospholipase A2 due to Human GH Treatment in Short Children with GH Deficiency and Small for Gestational Age Status
Andreas Krebs a , Thomas Kratzin a , Jürgen Doerfer a , Karl Winkler b , Michael Wurm a , Natascha van der Werf-Grohmann a , Alexandra Krause a & Karl Otfried Schwab a
aDepartment of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany; bDepartment of Clinical Chemistry, University Medical Center, Freiburg, Germany.
Objectives: GH deficiency (GHD) and small for gestational age (SGA) status are associated with cardiovascular risks. We therefore investigated antiatherogenic effects of GH.
Methods: Subfractions of LDL and HDL, lipoprotein-associated phospholipase A2 (Lp-PLA2), and high-sensitivity C-reactive protein (hsCRP) were measured at baseline, after 8 and 52 weeks of GH treatment in 51 short children born SGA (n=33) or with GHD (n=18).
Results: For the overall group, we found post-treatment reductions of LDL cholesterol (P=0.016), small-dense LDL cholesterol (P<0.001), Lp-PLA2 (P<0.001), and hsCRP (P=0.005), but increases of HDL2a cholesterol (P=0.025). SGA children showed reductions of small-dense LDL cholesterol (P=0.02), Lp-PLA2 (P=0.002), hsCRP (P=0.037) and increases of HDL2a cholesterol (P=0.004). GH deficient children had non-significant decreases of small-dense LDL cholesterol, Lp-PLA2, hsCRP and increases of HDL2a cholesterol.
Conclusions: Children with GHD or born SGA may benefit from GH treatment by growth acceleration and simultaneous reduction of their latent cardiovascular long-term risk.
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