ESPE Abstracts

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Background: Anorexia nervosa (AN) is a condition of severe malnutrition that impacts multiple endocrine axes, including the hypothalamic-pituitary-gonadal (HPG) axis. Although amenorrhea is no longer required for the diagnosis of AN (DSM-5), amenorrhea continues to be common in this disorder.Objective and hypotheses: This talk will review the prevalence and consequences of HPG axis suppression and amenorrhea in adolescents with AN....

Exercise-related reproductive dysfunction appears to be multifactorial in origin and remains a diagnosis of exclusion. The main factors etiologically correlated with menstrual disturbances in athletes are body composition, stress (physical exercise and psychological stress), energy balance (energy availability), diet, training methods (sports character) and reproductive maturity. Recent data highlight the endocrine role of the adipose tissue in the regulation of metabolism and...

Background: Less than 1% of breast cancer cases occur in women aged <25 years but young age at diagnosis is associated with an increased risk of recurrence and inferior survival compared to older patients. Breast tumours from young patients have an increased incidence of adverse pathological features; however it is not clear whether this fully explains poor outcomes.Objective and hypotheses: The Prospective Study of Outcomes in Sporadic and Hereditar...

Benign breast diseases (BBD) have always been neglected in comparison to cancer, despite the fact that there are many more patients with such diseases than patients presenting to a breast clinic for cancer, especially in young women. So far, BBD have been the subject of a relatively few isolated and unconnected studies, and earlier related work has often been ignored. This situation has led to a great deal of confusion, especially because different authors have their own nomen...