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55th Annual ESPE

Paris, France
10 Sep 2016 - 12 Sep 2016

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Paris, France: 10-12 September 2016 Further information

Poster Presentations

Fat Metabolism and Obesity P1

hrp0086p1-p442 | Fat Metabolism and Obesity P1 | ESPE2016

Placental and Cord Blood DNA Methylation Profiling in Small-for-Gestational-Age Newborns from Uncomplicated Pregnancies: Relationship to Prenatal Growth and Postnatal Body Composition

Diaz Marta , Garcia Cristina , Sebastiani Giorgia , Garcia Francesc , Lopez-Bermejo Abel , Ibanez Lourdes

Background: Fetal growth is partly regulated by epigenetic factors, such as DNA methylation. Altered methylation status in placental genes relates to gestational diabetes, preeclampsia and prematurity. However, the epigenetic mechanisms underlying fetal growth restraint in uncomplicated pregnancies remain unknown.Objective and hypotheses: We aimed at identifying new candidate genes related to fetal growth, by assessing DNA methylation profiling in placen...

hrp0086p1-p443 | Fat Metabolism and Obesity P1 | ESPE2016

The Collapse of the BDNF/POMC System in the Hypothalamus is Responsible for the Extreme Obesity with Hyperphagia Observed in Female Heterozygous MeCP2 Null Mice

Fukuhara Shota , Nakajima Hisakazu , Kodo Kazuki , Itoh Ikuyo , Shigehara Keiichi , Moroto Masaharu , Sugimoto Satoru , Mori Jun , Kosaka Kitaro , Morimoto Masafumi , Hosoi Hajime

Objective and hypotheses: The aim was to elucidate the mechanism underlying the extreme obesity observed in female heterozygous MeCP2 null mice fed a high-fat diet.Method: We examined the molecular biology and physiology of female heterozygous MeCP2 null mice (Mecp2tm1.1Bird/J, MeCP2+/− mice) fed a high-fat diet (HFD) for 12 weeks since 4 weeks of age using analytical tools. C57/BL6 mice were used as controls.<p class="abs...

hrp0086p1-p444 | Fat Metabolism and Obesity P1 | ESPE2016

Neonatal Overfeeding Alters Hepatic Insulin Sensitivity During Lactation and Leads to Long-term Insulin Resistance and Fatty Liver in Mice: Key Role of Mogat1

Ramon-Krauel Marta , Pentinat Thais , Cebria Judith , Vila Maria , Perez-Wienese Ricky , Kalko Susana , Tietge Uwe , Plosch Torsten , Diaz Ruben , Jimenez-Chillaron Josep

Background: Excessive energy intake and rapid weight gain early in life are associated with obesity, type 2 diabetes, hepatic steatosis and other features of the metabolic syndrome. The monoacylglycerol acyltransferase (MGAT) is an enzyme involved in an alternative pathway for triglyceride (TAG) synthesis and storage. It has been recently proposed to have potential implications in the pathogenesis of hepatic insulin resistance (IR).Objective: To understa...

hrp0086p1-p445 | Fat Metabolism and Obesity P1 | ESPE2016

The Impact of Activating PIK3CA Mutations and PTEN Haploinsufficiency on Human Adipocyte Phenotype and Biology

Kassner Franziska , Handel Norman , Leipert Jenny , Sauer Tina , Wilhelm Franziska , Landgraf Kathrin , Kiess Wieland , Korner Antje , Garten Antje

Background: The phosphatase and tensin homolog (PTEN)/phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway is central for cell cycle control, differentiation, migration, and metabolism. Unrestricted growth of adipose tissue in particular is frequently seen in humans with germline PTEN and mosaic activating PIK3CA mutations, respectively.Objective and hypotheses: We assume that adipocytes from affected tissue show hyperproliferation and modified dif...

hrp0086p1-p446 | Fat Metabolism and Obesity P1 | ESPE2016

Bioinactive Leptin is not Frequently Detected in Severe Early Onset Childhood Obesity

Stanik Juraj , Kratzsch Jurgen , Scheuermann Kathrin , Gašperikova Daniela , Kiess Wieland , Korner Antje

Background: Rodent models of leptin inactivity show progressive obesity due to exaggerated food intake. In humans, only rare monogenic cases of leptin deficiency and almost absent circulating leptin levels have been identified. Recently, two cases of children with early onset massive obesity due to biofunctionally inactive leptin in the face of normal total levels have been identified.Objective and hypotheses: Here we aimed to identify leptin inactivity ...

hrp0086p1-p447 | Fat Metabolism and Obesity P1 | ESPE2016

Neonatal Overnutrition Causes Sex and Age Dependant Long-Term Effects on Body Weight, Body Composition and Serum Triglyceride and Free Fatty Acid Levels

Argente-Arizon Pilar , Diaz Francisca , Fuente-Martin Esther , Chowen Julie Ann , Argente Jesus

Background: Neonatal over-nutrition (NON) can increase the propensity to become overweight and develop associated metabolic disturbances in later life. Moreover, some of these long-term effects are sexually dimorphic.Objective and hypotheses: We aimed to determine how NON affects body weight (BW), body composition and triglyceride (TG) and non-esterified fatty acids (NEFA) levels. We hypothesized that the effects would be both age and sex dependant.<...

hrp0086p1-p448 | Fat Metabolism and Obesity P1 | ESPE2016

Laparoscopic sleeve gastrectomy in adolescents with morbid and dynamic obesity. A controlled monocentric study.

Filippo Gianpaolo De , Pourcher Guillaume , Castell Anne Laure , Kyheng Christele , Bougneres Pierre

Background: Following years of dietary and lifestyle intervention (DLI) as the only therapeutic option, reports of bariatric surgery are emerging in adolescents with morbid obesity. We present herein preliminary results of our 4-yr sleeve gastrectomy study.Objectives and hypotheses: To compare the effects of laparoscopic sleeve gastrectomy (LSG) and intensive DLI in adolescents with morbid obesity (ie BMI >4 DS) and extremely active weight gain (i.e....

hrp0086p1-p449 | Fat Metabolism and Obesity P1 | ESPE2016

Efficacy, Safety and Metabolic Effects of Carbohydrate Restriction in the Treatment of Obese Adolescents

Martos-Moreno Gabriel A , Gonzalez-Leal Rocio , Argente Jesus

Background: Dietary carbohydrate restriction in the treatment of obese adolescents could cause a substantial shift in the substrates used as an energy source, inducing changes on body composition and metabolism, but experience in this age range is limited.Objective: We assessed the influence of 6 months of dietary carbohydrate restriction on body composition and lipid and carbohydrate metabolism in obese adolescents.Method: Thirty-...

hrp0086p1-p450 | Fat Metabolism and Obesity P1 | ESPE2016

Severe Hypertriglyceridemia in Pediatric Oncology Patient

Grau Gema , Portillo Nancy , Almaraz Ricardo Lopez , Echebarria Aizpea , Adan Rosa , Rodriguez Amaia , Vela Amaia , Astigarraga Itziar , Rica Itxaso

Background: Severe Hypertriglyceridemia (HTG) defined as triglycerides (TG) in blood plasma higher than 1000 mg/dl is a rare condition in childhood. Its causes are classified as primary and secondary and among these last they include pharmacological causes. Steroids associated with some chemotherapy drugs, particularly asparaginase (Asp), are a combination with special risk.Objective and hypotheses: Describe the evolution of lipids profile in LLA patient...

hrp0086p1-p451 | Fat Metabolism and Obesity P1 | ESPE2016

The Frequencies of 5-HTTLPR Locus in Promotor Part of Serotonine Transporter Gene (SLC6A4) Polymorphism in Children with Different Forms of Obesity

Zagrebaeva Olga , Solntsava Anzhalika , Aksyonova Elena , Seyitnazarova Ayjan , Dashkevich Helena

Background: Serotonine transporter gene (SLC6A4) polymorphism is one of genetic aspects of appetite and mood disorders.Objective and hypotheses: To determine the frequencies of 5-HTTLPR locus in promotor part of serotonine transporter gene (SLC6A4) polymorphism in children with different forms of obesity.Method: We examined 191 pubertal obese children. Patients were divided: Group 1 (simple obesity) 143 children, 14.3±1.8 year...

hrp0086p1-p452 | Fat Metabolism and Obesity P1 | ESPE2016

High Predictability of Impaired Glucose Tolerance by Combining Diagnostic Parameters in Obese Children

Jan de Groot Cornelis , van der Grond Jeroen , Delgado Yosine , Rings Edmond , Hannema Sabine , van den Akker Erica

Background: Current guidelines suggest to test obese subjects with impaired fasting glucose (IFG) by oral glucose tolerance test (OGTT) for the presence of type 2 diabetes. This strategy, however, misses most cases of impaired glucose tolerance (IGT).Objective and hypotheses: To investigate whether combining risk factors improves predictability of IGT in OGTT.Method: In this observational study of 145 overweight children, aged 2.5&...

hrp0086p1-p453 | Fat Metabolism and Obesity P1 | ESPE2016

The Effect of Subclinical Hypothyroidism (SH) and Treatment of SH with L-T4 on Basal Metabolic Rate in Obese Children: A Prospective Study

Muzafferova Nigar , Bas Serpil , Atay Zeynep , Bereket Abdullah , Turan Serap

Introduction: Subclinical hypothyroidism (SH) is reported up to 20% of obese population and thyroid hormone replacement in these individuals are controversial. In this study, we aimed to determine the effect of thyroid hormones on basal metabolic rate (BMR) in obesity and, thyroid hormone replacement on BMH and weight in obese patients with SH.Method: The study was conducted in 31 obese children (15 of them had subclinical hypothyroidism) admitted to our...

hrp0086p1-p454 | Fat Metabolism and Obesity P1 | ESPE2016

Influence of Television Viewing During Meals on Eating Patterns

Leis Trabazo Rosaura , Vazquez-Cobela Rocio , Jose Bedoya Carpente Juan , Aguilera Garcia Concepcion , Olza Meneses Josune , Gil-Campos Mercedes , Bueno Lozano Gloria , Gil Hernandez Angel , Moreno Aznar Luis , Tojo Sierra Rafel

Background: Recent studies show negative impact of the use of television while having food on the eating patterns.Objective and hypotheses: Our goal is to use cluster analysis to evaluate this influence in children.Method: In 895 Spanish children and adolescents (47% male and 53% female), from 3 to 18 years of age (10.25±2.67 years), a validated food frequency and food consumption habits questionnaire (CFCA) is performed. Thre...

hrp0086p1-p455 | Fat Metabolism and Obesity P1 | ESPE2016

Seven-year Follow-up of Mothers from a Randomized Controlled Trial of Exercise in Pregnancy and their Offspring

Chiavaroli Valentina , Hopkins Sarah , Derraik Jose , Seneviratne Sumudu , Biggs Janene , Rodrigues Raquel , Cutfield Wayne , Hofman Paul

Background: We have previously shown in a randomised controlled trial that moderate-intensity exercise over the last 20 weeks of gestation in healthy nulliparous women led to a birth weight reduction of approximately 250 g.Objective and hypotheses: We aimed to assess the long-term effects of exercise in pregnancy on anthropometry and body composition in mothers and offspring 7 years after the intervention. We hypothesized that women who exercised in preg...

hrp0086p1-p456 | Fat Metabolism and Obesity P1 | ESPE2016

E-Health: A National Registry and Therapeutic Algorithm for the Prevention and Management of Overweight and Obesity in Childhood and Adolescence in Greece

Kassari Penio , Papaioannou Panagiotis , Billiris Antonis , Karanikas Haralampos , Eleftheriou Stergiani , Thireos Eleftherios , Manios Yannis , Chrousos George P. , Charmandari Evangelia

Background: Obesity in childhood and adolescence represents a major health problem of our century and accounts for a significant increase in morbidity and mortality in adulthood. In Greece, more than 35% of children and adolescents are currently overweight or obese.Objective and hypotheses: To develop a National e-Health System for General Pediatricians and General Practitioners for the prevention and management of overweight and obesity. Specific aims i...

hrp0086p1-p457 | Fat Metabolism and Obesity P1 | ESPE2016

Premature Adrenarche and Metabolic Risk: Differences by Gender

Pereira Ana , Merino Paulina M. , Iniguez German , Corvalan Camila , Mericq Veronica

Background: Premature adrenarche (PA) has been considered a benign condition. Recently, associations with an increased metabolic risk have arisen. This risk may depend on ethnic background and infancy weight gain, which could be different by gender.Objective and hypotheses: To determine whether PA in children at pubertal onset (TII) determines a higher metabolic profile.Methods: 1190 children (49.9% female) from the longitudinal co...

hrp0086p1-p458 | Fat Metabolism and Obesity P1 | ESPE2016

Association of miR-34a and mir-149 with Obesity and Insulin Resistance in Obese Children and Adolescents

Nourbakhsh Mitra , Ahmadpour Fatemeh , Khaghani Shahnaz , Alipour Behnam , Razzaghy Azar Maryam

Background: Obesity is a major public health problem and its rate is increasing worldwide. Obesity accompanies perturbations in metabolism, conferring substantial excess risk for insulin resistance and Type 2 diabetes. Various genetic and epigenetic factors contribute to the development of obesity. MicroRNAs (miRNAs) are short noncoding RNAs involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipid metabolis...

hrp0086p1-p459 | Fat Metabolism and Obesity P1 | ESPE2016

Erythropoietin Activates Classical Brown Adipose Tissue Through the Erythropoietin Receptor/STAT3 Pathway, Improving Obesity and Glucose Homeostasis in High Fat Diet-induced Obese Mice

Kodo Kazuki , Nakajima Hisakazu , Sugimoto Satoru , Itoh Ikuyo , Syota Fukuhara , Shigehara Keiichi , Nishikawa Taichiro , Mori Jun , Kosaka Kitaro , Hosoi Hajime

Background, aims and objectives: We hypothesized that classical brown adipose tissue (cBAT) could play a crucial role in the anti-obesity effects of erythropoietin (EPO). Our study highlights the mechanism in which EPO treatments could upregulate energy expenditure and improve glucose homeostasis through cBAT in obese mice fed with a high-fat diet (HFD).Method: C57BL/6J mice had been fed with HFD since the age of 4 weeks (HFD mice). We administered recom...

hrp0086p1-p460 | Fat Metabolism and Obesity P1 | ESPE2016

The Association between Insulin Resistance and Lower Extremity Muscle Strength, Static and Dynamic Standing Balances in Obese Adolescents

Akinci Aysehan , Ersoy Yuksel , Dundar Ismaıl

Background: Obesity is characterized by insulin resistance of target tissues, such as skeletal muscle, adipose tissue and liver. Skeletal muscle tissue is responsible for approximately 75% of whole body insulin-stimulated glucose uptake. Previously, it has been shown that skeletal muscle strength is significantly associated with insulin resistance in type-2 diabetics and non-diabetics.Objective and hypotheses: To examine the relationship between insulin ...

hrp0086p1-p461 | Fat Metabolism and Obesity P1 | ESPE2016

Adiponectin and IL-6 in Simple Childhood Obesity with and without Hepatic Steatosis

Stagi Stefano , Nanni Laura , Scalini Perla , Luisa Vetrano Maria , Mirri Silvia , de Martino Maurizio , Seminara Salvatore

Background: Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of clinicopathological conditions frequently discovered in obese patients and characterized by multifactorial pathogenesis. Hypoadiponectinaemia and higher interleukin (IL)-6 levels has been related to NAFLD, even if some contradictory findings have emphasized our incomplete understanding of the role of the cytokines in NAFLD.Objective and hypotheses: To investigate the relations...

hrp0086p1-p462 | Fat Metabolism and Obesity P1 | ESPE2016

Determinants of Advanced Bone Age in Childhood Obesity

Jan de Groot Cornelis , van den Berg Adriaan , Ballieux Bart , Kroon Herman , Rings Edmond , Maarten Wit Jan , van den Akker Erica

Background: Childhood obesity is associated with advanced bone age (BA), leading to an altered growth pattern. Previous results of studies suggest that androgens, estrogens, sex hormone binding globulin (SHBG) and insulin are responsible for this phenomenon, but results are contradictory and might be biased by confounders.Objective and hypotheses: To investigate the independent effects of estrogens, androgens, SHBG and insulin parameters on BA advancemen...

hrp0086p1-p463 | Fat Metabolism and Obesity P1 | ESPE2016

Exposure to Phthalates Is Associated with Overweight or Obesity in 4-Year-Old Children

Lee Jieun , Ah Lee Young , Woon Jung Hae , Young Kim Hwa , Min Lee Gyung , Youn Kim So , Jeong Kyung A. , Hee Choi Keun , Lim Youn-Hee , Bae Sanghyuk , Hong Yun-Chul , Ho Shin Choong , Won Yang Sei

Background: Childhood obesity is a major health concern. Exposure to environmental chemicals may play a role in childhood obesity.Objective and hypotheses: We investigated whether urinary phthalate metabolite concentrations was associated with overweight or obese status in 4-year-old children.Method: Forty-hundred thirteen children born as term, appropriate-for-gestational-age infants (226 males) were included in this study. BMI wa...

hrp0086p1-p464 | Fat Metabolism and Obesity P1 | ESPE2016

Central Obesity among European Preschool Children: The ToyBox-Study

Galcheva Sonya , Lateva Mina , Iotova Violeta , Androutsos Odysseas , Manios Yannis , De Bourdeaudhuij Ilse , Cardon Greet , Socha Piotr , Moreno Luis , Koletzko Berthold , on behalf of ToyBox-Study Group

Background: Waist circumference (WC) reflects the fat distribution and the degree of central adiposity in children, which is specifically associated with cardiovascular risk factors and useful as a component of metabolic syndrome definition in children.Objective and hypotheses: To evaluate the distribution of WC measures among preschool children aged 3.5–5.5 years from six European countries.Method: Cross-sectional study of a ...

hrp0086p1-p465 | Fat Metabolism and Obesity P1 | ESPE2016

Changes in Waist-to-Height Ratio during Preschool Years Differ between Children being Obese or Overweight at Five Years of Age Compared with not Overweight Children

Lindholm Annelie , Roswall Josefine , Almqvist-Tangen Gerd , Alm Bernt , Dahlgren Jovanna , Bergman Stefan

Background: Growth patterns in early childhood are important for predicting adult overweight or obesity. BMI is the most widely used measure. However BMI does not reveal much regarding the distribution of fat, for example the visceral fat that in adults is highly correlated with metabolic risk. Waist-to-Height Ratio (WtHR) is in adults a better measure for visceral fat and studies indicate that the same applies to children.Objective and hypotheses: To st...

hrp0086p1-p466 | Fat Metabolism and Obesity P1 | ESPE2016

Remarkable Increase in the Prevalence of Overweight and Obesity among School Age Children in Antalya, Turkey, between 2003 and 2015

Celmeli Gamze , Curek Yusuf , Arslan Zumrut , Yardimsever Mehmet , Koyun Mustafa , Akcurin Sema , Bircan Iffet

Background: The prevalence of childhood obesity is increasing all over the world and leading to an increase in obesity-related health problems such as adult obesity, cardiovascular diseases, type 2 diabetes and depression. There is no nationwide systematic study investigating obesity trends in Turkish children.Objective and hypotheses: The aim of this study is to determine the prevalence of overweight and obesity among school age children, to compare the...

hrp0086p1-p467 | Fat Metabolism and Obesity P1 | ESPE2016

The Peculiarities of Neurotransmitters Levels in Children with Obesity and Different Genotypes of COMT Gene

Zagrebaeva Olga , Solntsava Anzhalika , Aksyonova Elena , Seyitnazarova Ayjan , Dashkevich Helena

Background: Polymorphic genes Val158Met gene catechol-O-metiltrasferaz (COMT) are used to be responsible for less neurotransmitters utilization.Objective and hypotheses: To determine the peculiarities of neurotransmitters levels in children with obesity and different genotypes of COMT gene.Method: We examined 191 pubertal obese children. Patients were divided: Group1 (simple obesity) 143 children, 14.3±1.8 years, 30.6±2.8...

hrp0086p1-p468 | Fat Metabolism and Obesity P1 | ESPE2016

Association of Fasting Triglycerides to High-Density Lipoprotein Ratio with Risk for Metabolic Disorders in Children

Efthymia Katsa Maria , Ioannidis Anastasios , Zyga Sofia , Sachlas Athanasios , Tsironi Maria , Paola Rojas Gil Andrea

Background: Atherosclerosis begins in childhood and progresses silently. Triglycerides/HDL ratio(TG/HDL) is a risk factor for cardiovascular diseases.Objective and hypotheses: To investigate TG/HDL as possible predictive factor for metabolic disorders in children.Method: Descriptive correlation, with 110 children (6–12 years old) in Sparta, Greece. Anthropometric and biochemical analyzes were performed.R...

hrp0086p1-p469 | Fat Metabolism and Obesity P1 | ESPE2016

Assessment of Adherence to Mediterranean Diet during a Weight Loss Intervention in Children with Cardiometabolic Risk

Morell-Azanza Lydia , Ochotorena-Elicegui Amaia , Catalan-Lamban Ana , Chueca Maria , Marti Amelia , Azcona San Julian Cristina

Background: Dietary patterns have notably changed in Mediterranean countries during the last decades. Mediterranean diet (MeDiet) is associated with lower prevalence of cardiometabolic diseases.Objective and hypotheses: To assess adherence to MeDiet in children and adolescents with abdominal obesity during a comprehensive weight loss intervention.Method: Children and adolescents with abdominal obesity (waist circumference >p90)...

hrp0086p1-p470 | Fat Metabolism and Obesity P1 | ESPE2016

Brain Structure, Executive Function and Appetitive Traits in Adolescent Obesity

Jan de Groot Cornelis , van den Akker Erica , Rings Edmond , Delemarre-van de Waal Henriette , van der Grond Jeroen

Background: Children with obesity show differences in brain structure, executive function and appetitive traits when compared to lean peers. Results of imaging studies, however, have been contradictory.Objective and hypotheses: To investigate whether childhood obesity is associated with differences in brain structure and whether differences associate with executive function and appetitive traits.Method: A cross-sectional case-contr...

hrp0086p1-p471 | Fat Metabolism and Obesity P1 | ESPE2016

Improved Clinical and Laboratory Changes after 12 Months of Use of Metformin in Obese Insulin Resistant Children and Adolescents

Cominato Louise , Rocha Ruth , Renie Oliveira Rachid Ludmilla , Filgueiras Vilaca Duarte Nathalia , Cinquini Freitas Franco Natalia , Ybarra Marina , Steinmetz Leandra , Damiani Durval

Background: Childhood obesity is one of the most prevalent and challenging health care concerns. In this context, insulin resistance (IR) is an important disorder with strong association with metabolic (type 2 diabetes, hypercholesterolemia) and cardiovascular (hypertension, atherosclerosis) outcomes. Clinical trials have been showing Metformin as an effective drug on reducing the IR and BMI. However, there is little data on use of metformin in children....

hrp0086p1-p472 | Fat Metabolism and Obesity P1 | ESPE2016

Risk factors for Atherosclerosis after Anticancer Treatment in Childhood: The Assessment of Lipid Parameters and Indicators of Susceptibility to Atherosclerosis in a Group of Pediatric Patients after Anticancer Treatment

Połubok Joanna , Jasielska Olimpia , Gonera Aleksandra , Kozicka Marta , Sęga-Pondel Dorota , Kazanowska Bernarda , Barg Barg

Introduction: Lipid disorders are a common complication of anticancer therapy. These disorders may be included in both the metabolic syndrome or also may be associated with increased risk of cardiovascular disease. The aim of our study is to evaluate lipid profile in children after anticancer treatment.Materials and methods: Study group consisted of 44 patients (aged 3.25–16 years) with solid tumors, at least one year after cessation of anticancer t...

hrp0086p1-p473 | Fat Metabolism and Obesity P1 | ESPE2016

Inherited Duplication (X) (p11.4) Associated with Obesity, Autoaggressive Behaviour and Delayed Speech Development

Doeing Carsten , Rahner Nils , Kummer Sebastian , Meissner Thomas , Mayatepek Ertan

Background: Obesity is a major feature in several syndromes. In patients with early-onset severe obesity, 7% harbour a single locus mutation.Objective and hypotheses: We report a 3.11 year old male patient with early onset obesity (BMI 29.9 kg/m2 >>P97), ongoing excessive weight gain, autoaggressive behaviour, and delayed speech development. No growth retardation or further dysmorphic signs. Early postnatal feeding difficulties require...

hrp0086p1-p474 | Fat Metabolism and Obesity P1 | ESPE2016

Switching Patients with Congenital Hyperinsulinism from Standard Octreotide to Long-Acting Release Octreotide Preserves Blood Glucose Control and Improves Quality of Life of Their Caregivers

Piona Claudia , Maines Evelina , Baggio Laura , Gugelmo Giorgia , Cavarzere Paolo , Bordugo Andrea , Gaudino Rossella

Background: Congenital hyperinsulinism (CHI; MIM #256450) is the most common cause of persistent hypoglycaemia in children. Recessive inactivating mutations in KATP channel subunits, encoded by ABCC8 and KCNJ11 genes, are the most common cause of CHI. Mutations of these genes usually cause forms of CHI which in the vast majority of patients are unresponsive to first line medical treatment with diazoxide. Multiple daily standard octreotide injections combine...

hrp0086p1-p475 | Fat Metabolism and Obesity P1 | ESPE2016

Reduction of Body Mass and Change in Body Composition of the Participants of the PoZdro! – Programme for Prevention of Diabetes and Civilisation Diseases by Medicover Foundation – Preliminary Results, after the First Year of Interventions

Magnuszewska Hanna , Anyszek Tomasz , Brzezinski Michal , Lech Monika , Soszynski Piotr , Walewski Jacek , Szarejko Kamila , Radziwill Marcin , Mysliwiec Malgorzata , Czupryniak Leszek

Background: Lifestyle interventions are basic tool to treat obesity in the youth. They prevent from civilisation diseases. Globally, there are many programmes including regular meetings with dieticians, exercise specialists, and others. Results are promising, although there’s no consensus regarding one model of recommended diet, exercise’s intensity and frequency of interventions.Objective and hypotheses: Assessment of preliminary results of &#...

hrp0086p1-p476 | Fat Metabolism and Obesity P1 | ESPE2016

Polysomnography in Obese Children with and without Prader-Willi

Bogova Elena , Volevodz Natalya , Peterkova Valentina , Poluektov Mikhail

Background: Several studies found a high prevalence of sleep disorders in PWS patients. It is assumed that Prader-Willi Syndrome (PWS) patients are at a high risk of sleep disordered breathing, such as obstructive sleep apnea (OSA), because of their childhood obesity, associated with muscle hypotonia, leading to upper airway collapse.Objective and hypotheses: We studied a group of PWS children (genetically confirmed, non-GH-treated) who performed complet...

hrp0086p1-p477 | Fat Metabolism and Obesity P1 | ESPE2016

Renal Involvement ın Obese Children and Adolescents

Kaya Mehmet Sirin , Anık Ahmet , Unuvar Tolga , Sonmez Ferah

Background and aim: Epidemiologic studies have been shown that obesity increases the risk of renal disease and it impact on prognosis. In this study, we aimed to investigate both glomerular and tubular involvement in asymptomatic obese children and to investigate the association of metabolic-anthropometric parameters with renal parameters.Material-method: Children with BMI ≥95th percentile and diagnosed as primary obesity (n=43) were inclu...

hrp0086p1-p478 | Fat Metabolism and Obesity P1 | ESPE2016

BMI Correlates Positively with Hair Cortisol, whereas Excessive Body Fat Correlates Positively with Hair Cortisol: Salivary Cortisol and Fasting Insulin Concentrations in Prepubertal Girls

Christaki Eirini , Papafotiou Chrysanthe , Bastaki Despoina , van den Akker Erica L.T. , Wester Vincent L. , Boschiero Dario , Pervanidou Panagiota , Kanaka-Gantenbein Christina , Chrousos George

Background: Chronic stress and increased adiposity have been associated with each other in children. Further studies are needed, however, to evaluate both the directionality of this association and the mediating metabolic mechanisms.Objective and hypotheses: This study investigates the interrelations between BMI, body composition parameters, indices of the stress response, such as hair and salivary cortisol levels, and, metabolic mediators, such as insul...

hrp0086p1-p479 | Fat Metabolism and Obesity P1 | ESPE2016

Hepatic Steatosis and Cardiovascular Risk in Overweight Children: Preliminary Results of the Study EFIGRO

Diez-Lopez Ignacio , Sarasua Ainhoa , Medrano Maria , Arenaza Lyde , Rodriguez-Vigil Beatriz , Tobalina Ignacio , Larrarte Eider , Perez-Asenjo Javier , Labayen Idoia

Introduction: The accumulation of fat in the liver is a serious complication of childhood obesity seems to be associated with cardiometabolic risk.Objective: To examine the association between fat accumulation in the liver and cardiovascular risk factors in overweight children.Material and methods: In the study 68 children/as (51.4% girls) were overweight or obese (defined according to the classification criteria of the Internation...

hrp0086p1-p480 | Fat Metabolism and Obesity P1 | ESPE2016

Associations of Different Appetite Hormones with Physical Activity and Cardiorespiratory Fitness in Adolescent Boys with Different BMI Values

Tillmann Vallo , Remmel Liina , Purge Priit , Latt Evelin , Jurimae Jaak

Background: Higher physical activity (PA) attenuates the health risks of obesity and has positive effects on body weight reduction. The results of our recent longitudinal study showed that PA, especially vigorous PA (VPA), is an important factor for predicting overweight in boys during puberty (Lätt et al., 2015).Objective and hypotheses: The aim of this study was to examine the associations of fasting serum acylated and des-acylated ghreli...

hrp0086p1-p481 | Fat Metabolism and Obesity P1 | ESPE2016

The Relation of Glycaemic Variability Obtained by Continuous Subcutaneous Glucose Monitoring with IL-6 and Adiponectin Levels in Obese Children with Metabolic Syndrome and Insulin Resistance

Kaya Abdurrahman , Kocyigit Cemil , Catli Gonul , Can Penbe S. , Sutcu Recep , Dundar Bumin N.

Background: Increased glycaemic variability (GV) (short-term fluctuations in blood glucose level) is associated with increased oxidative stress, vascular complications and mortality in diabetic and prediabetic patients.Objective and hypotheses: To investigate the relationship between GV and inflammatory markers in obese children with metabolic syndrome (MS) and insulin resistance (IR).Method: Fifty obese adolescents with insulin re...

hrp0086p1-p482 | Fat Metabolism and Obesity P1 | ESPE2016

Changes in Urine and Plasma Metabolomics Profiles after a Lifestyle Intervention Program in Obese Prepubertal Children

Jesus Leal Witt Maria , Llobet Marina , Samino Sara , Rodriguez Miguel A. , Yanes Oscar , Ramon Marta , Lerin Carles

Background: Obesity is one of the major risk factor for metabolic and cardiovascular disorders, and its global prevalence has increased exponentially in the last decades. Excessive weight gained during early childhood increases long-term risk; however, reversing this condition during early-life reduces risk, improving children’s quality of life.Objective and hypotheses: We hypothesized that a lifestyle intervention in obese prepubertal children woul...

hrp0086p1-p483 | Fat Metabolism and Obesity P1 | ESPE2016

The Effectiveness of a Stress Management Intervention Program in the Management of Overweight and Obesity in Childhood and Adolescence

Stavrou Stavroula , Nicolaides Nicolas C. , Papageorgiou Ifigeneia , Papadopoulou Pinelopi , Terzioglou Eleni , Darviri Christina , Chrousos George P. , Charmandari Evangelia

Background: Obesity in childhood and adolescence represents a major health problem of our century, and accounts for a significant increase in morbidity and mortality in adulthood. In addition to the increased consumption of calories and lack of exercise, accumulating evidence suggests that childhood obesity is strongly associated with prolonged and excessive activation of the stress system.Objective and hypotheses: The aim of our study was to assess the ...

hrp0086p1-p484 | Fat Metabolism and Obesity P1 | ESPE2016

Fetuin-A as an Alternative Marker for Insulin Resistance and Cardiovascular Risk in Prepubertal Children

Joung Oh Yeon , Hee Yi Kyung , Jae Kang Min , Woo Baek Joon , Yang Seung , Tae Hwang Il

Background: Fetuin-A plays a role in insulin resistance and cardiovascular disease.Objective and hypotheses: The aim of present study was to determine the relation between fetuin-A levels and caridiometabolic risk factors and to investigate effect of serum fetuin-A to insulin sensitivity indices for determining whether fetuin-A is additional marker of insulin resistance in prepubertal children.Method: Ninety-nine prepubertal Korean...

hrp0086p1-p485 | Fat Metabolism and Obesity P1 | ESPE2016

What are Early Predictors of Impaired Glucose Tolerance in Children Born SGA?

Petraitiene Indre , Jasinskiene Edita , Albertsson-Wikland Kerstin , Verkauskiene Rasa

Background: Subjects born small for gestational age (SGA) were shown to be at higher risk to later metabolic consequences but early prediction factors of changes in glucose metabolism are not clearly known.Objective and hypotheses: We aimed to investigate glucose tolerance and insulin resistance in adolescents born SGA or appropriate for gestational age (AGA) and their relationship with perinatal and postnatal factors.Method: A pro...

hrp0086p1-p486 | Fat Metabolism and Obesity P1 | ESPE2016

Multidisciplinary Intervention Programme in Childhood Obesity- Review of Service

Jones Jeremy , Wallach Peri , Knoud Ellis , Hind Ruth , Robinson Susan , Morrison Jillian , Shaikh M Guftar

Background: A multidisciplinary team (MDT) intervention may improve severe obesity in children through education and life-style change.Objective and hypotheses: MDT intervention leads to improvements in clinical measures of obesity.Method: Participants were selected by criteria: <16 years old; BMI >3.5SDS or BMI >2.5 SDS with obesity-related co-morbidity. Children and their families, attended intervention sessions over ...

hrp0086p1-p487 | Fat Metabolism and Obesity P1 | ESPE2016

Hypercholesterolemia in Childhood: How the Response to Diet could Lead to Diagnosis. Lesson from a Case-Report

Bruzzi Patrizia , Predieri Barbara , Filomena Madeo Simona , Rabacchi Claudio , Tarugi Patrizia , Calandra Sebastiano , Iughetti Lorenzo

Background: Sitosterolemia is a rare autosomal recessive disorder characterized by intestinal hyperabsorption and decreased biliary excretion of dietary plant sterol, due to mutations in adenosine-triphosphate (ATP)-binding-cassette (ABC) transporter family (ABCG8 and ABCG5).Case report: A 7.86 years old boy was referred to the Childhood Lipid Clinic due to incidental finding of hypercholesterolemia: total cholesterol 524 mg/dl (13.54 mmol/l), LDL-choles...

hrp0086p1-p488 | Fat Metabolism and Obesity P1 | ESPE2016

Glucose Metabolism In Children with Prader-Willi Syndrome: The Effect Of Gh Therapy

Grugni Graziano , Fintini Danilo , Bocchini Sarah , Crino Antonino

Background: Numerous studies have shown that PWS patients demonstrate the preservation of insulin sensitivity despite severe obesity. Data about insulin secretion in PWS however, are still conflicting. Other reports showed that PWS subjects and simple obese controls had similar insulin levels and were both insulin resistant. These discrepancies could be due to the different clinical characteristics of the study groups, including age, weight excess levels and the presence/absen...

hrp0086p1-p489 | Fat Metabolism and Obesity P1 | ESPE2016

Impact of a Group-based Treatment Program on Adipocytokines, Oxidative status, Inflammatory Cytokines, and Pulse Wave Velocity in Obese Children and Adolescents

Santiprabhob Jeerunda , Limprayoon Kawewan , Aanpreung Prapun , Charoensakdi Ratiya , Kalpravidh Ruchaneekorn W. , Phonrat Benjaluck , Tungtrongchitr Rungsunn

Background: The link between obesity and dysregulation of adipocytokines, inflammatory cytokines, and oxidative status has been found to underline the pathogenesis of obesity-related complications, such as cardiovascular disease and type 2 diabetes.Objective and hypotheses: The objectives were i) to evaluate the effect of a group-based lifestyle modification program on adipocytokines, inflammatory cytokines, oxidative status, and brachial-ankle pulse wav...