ESPE Abstracts (2016) 86 P-P1-223

The Relationship between the Serum Irisin Levels and the Metabolic Control in adolescents with Type 1 Diabetes

Aysegul Yuksel, Gulcan Seymen Karabulut, Canan Baydemir, Gul Yesiltepe Mutlu, Serkan Isgoren, Mustafa Cekmen & Sukru Hatun


Pediatric Endocrinology and Diabetes, Faculty of Medicine, Clinic/Kocaeli University, Kocaeli, Turkey


Background: Irisin is an adipomyokine secreted by many tissues. Because it has known relationships with the energy metabolism and exercise, its relationships with obesity and type 2 diabetes (T2D) are being focused on. Its relationship with type 1 diabetes (T1D) is unknown.

Objective and hypotheses: In this study, the relationships between the serum irisin level and the metabolic control were investigated in adolescents with T1D.

Method: The study group consisted of 125 T1D patients with diabetes duration of at least 2 years, 57 obese and 44 non-obese children, all were aged between 10 and 18 years. The metabolic parameters, anthropometric characteristics and body fat distributions and z-scores (by DXA) were measured and relationships of these with the serum irisin levels were examined.

Results: When all subjects were evaluated together, irisin levels were 3.08 (2.54–3.54) mcg/ml in girls and 3.12 (2.52–3.46) mcg/ml in boys, and no significant difference was found according to gender (P>0.05). When the serum irisin levels of the T1D, obese and normal patient groups (3.20 (2.78–3.66), 3.08 (2.46–3.42) and 2.60 (2.17–3.19) mcg/ml respectively) were analyzed, irisin levels in the diabetic group were found to be significantly higher (P<0.001).

Conclusion: Serum irisin levels of T1D adolescents were higher than the group consisting of obese and non-obese individuals.

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