Background: Irisin is an adipomyokine secreted by many tissues. Because it has known relationships with the energy metabolism and exercise, its relationships with obesity and type 2 diabetes (T2D) are being focused on. Its relationship with type 1 diabetes (T1D) is unknown.
Objective and hypotheses: In this study, the relationships between the serum irisin level and the metabolic control were investigated in adolescents with T1D.
Method: The study group consisted of 125 T1D patients with diabetes duration of at least 2 years, 57 obese and 44 non-obese children, all were aged between 10 and 18 years. The metabolic parameters, anthropometric characteristics and body fat distributions and z-scores (by DXA) were measured and relationships of these with the serum irisin levels were examined.
Results: When all subjects were evaluated together, irisin levels were 3.08 (2.543.54) mcg/ml in girls and 3.12 (2.523.46) mcg/ml in boys, and no significant difference was found according to gender (P>0.05). When the serum irisin levels of the T1D, obese and normal patient groups (3.20 (2.783.66), 3.08 (2.463.42) and 2.60 (2.173.19) mcg/ml respectively) were analyzed, irisin levels in the diabetic group were found to be significantly higher (P<0.001).
Conclusion: Serum irisin levels of T1D adolescents were higher than the group consisting of obese and non-obese individuals.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology