Background and aim: Epidemiologic studies have been shown that obesity increases the risk of renal disease and it impact on prognosis. In this study, we aimed to investigate both glomerular and tubular involvement in asymptomatic obese children and to investigate the association of metabolic-anthropometric parameters with renal parameters.
Material-method: Children with BMI ≥95th percentile and diagnosed as primary obesity (n=43) were included to this study. Also, sex and age matched healthy control subjects (n=43) with BMI <85th percentile were also included. Anthropometric parameters of all subjects were evaluated, and blood creatinine and sistatin C, 24h urine microalbumin, protein, N-asetil-β-D glucoseaminidase (NAG), sodium and transphorming growth factor-beta (TGF-β) levels were measured. Glomerular filtration rate (GFR) was calculated according to Schwartz formula. Renal structure and volumes were calculated by ultrasonography.
Results: Waist to hip ratio, both systolic and diastolic blood pressures, 24 h protein, microalbumin and sodium excretion and renal volumes were higher in obese children than control subjects (P<0.05). There was no difference between the groups for serum sistatin C and creatinine, GFR, 24 h TGF-β and NAG levels. There was positive correlation between BMI and systolic-diastolic blood pressure, GFR, microalbumin-sodium excretion and renal volumes in obese children. Beside, waist to hip ratio was positively correlated with systolic and diastolic blood pressure, 24 h microalbumin and sodium excretion in control subjects.
Conclusion: Obesity seems to effect glomerular and tubular functions negatively.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology