Background: Fetuin-A plays a role in insulin resistance and cardiovascular disease.
Objective and hypotheses: The aim of present study was to determine the relation between fetuin-A levels and caridiometabolic risk factors and to investigate effect of serum fetuin-A to insulin sensitivity indices for determining whether fetuin-A is additional marker of insulin resistance in prepubertal children.
Method: Ninety-nine prepubertal Korean children (59 males) with ages ranging from 6.0 to 10.0 years were included in this study. Subjects were divided into groups as normal-weighted and overweight/obese groups. Serum fetuin-A levels were measured using an enzyme-linked immunosorbent assay.
Results: Serum fetuin-A concentrations were significantly elevated in overweight/obese children (P=0.029). Serum fetuin-A were significantly positively correlated with BMI SDS (r=0.239, P=0.017), TG (r=0.285, P=0.004), insulin (r=0.377, P<0.001), HOMA-IR (r=0.365, P<0.001), systolic blood pressure (BP) (r=0.018, P=0.006) and diastolic BP (r=0.018, P=0.006) and were significantly inversely correlated with HDL cholesterol (r=−0.256, P=0.019). When adjusted for age, sex, BMI and lipid profiles in multivariate linear regression analysis, fetuin-A was significantly positively associated with homeostasis model assessment of insulin resistance (HOMA-IR) (P=0.048), and was marginally inversely associated with QUICKI (P=0.054).
Conclusion: Our results suggested that fetuin-A can be an alternative marker for insulin resistance and cardiovasucular risk in prepubertal children.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology