ESPE Abstracts (2016) 86 P-P2-330

Lipid Metabolism in Children with Diabetes Mellitus Type 1

Dmitri Latysheva, Oleg Latyshevb, Elena Kiselevab, Goar Okminyanb & Yuri Lobanova


aAltai State Medical University, Barnaul, Russia; bRMAPES, Moscow, Russia


Objective and hypotheses: To study the lipid metabolism in children with diabetes type 1.

Method: It was included 44 children (33 girls), the average age – 10.2±3.3 years. Patients were divided: group 1 (less than 5 years) – 23 children (17 girls), mean age 9.8±3.6, the average length of diabetes 2.08±1.5 years. The second (over 5 years) – 21 children (16 girls), mean age of 11.6±2.4, the average length – 7.5±1.6 years.

Results: The average content of lipids was: cholesterol 4.51±0.92 mmol/l, β-lipoproteins – 46.16±15.23 IU, HDL – 1.43±0.63 mmol/l, LDL – 2.72±0.98 mmol/l. Elevated cholesterol occurred in 13.6% (6/44), β-lipoproteins in 25% (11/44), LDL in 2.3% (1/44). Reduced HDL cholesterol was observed in 11.4% (1/44) of patients. No differences were found between the groups in the cholesterol (4.28±0.69 vs 4.77±1.08 mmol/l), β-lipoproteins (47.61±13.65 vs 47.43±18.56), LDL (2.59±0.8 vs 2.87±1.15 mmol/l), HDL (1.29±0.54 vs 1.29±0.67 mmol\l), atherogenic index (3.03±2.3 vs 3.3±1.6). It is not revealed differences in the incidence of pathological content of β-lipoprotein (17.3% (4/23) vs 33.3% (7/21)), HDL cholesterol (8.7% (2/23 vs 14.3% (3/21)) and LDL (0% vs 4.7% (1/21)). The tendency for a greater frequency of hypercholesterolemia in a group 1 (23.8% (5/21) vs 4.3% (1\23), P=0.150) A direct correlation relationship between the HbA1c and cholesterol (r=0.384, P=0.01), and LDL cholesterol (r=0.311, P=0.04).

Conclusion: The tendency of the relationship between diabetes duration and frequency of hypercholesterolemia. A direct relationship between the degree of compensation and LDL cholesterol disease.

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