ESPE Abstracts (2016) 86 P-P2-537

Insulin Resistance for Adolescents with Obesity in Latvia

Jurgita Gailitea,b, Olga Lubinaa, Eliza Salijumab, Ilze Napituhinaa, Karina Agadzanjanaa, Irena Stundzanea, Inara Kirillovaa, Una Lauga-Tuninaa, Anita Vetraa,b & Iveta Dzivite-Krisanea,b


aChildren’s Clinical University Hospital, Riga, Latvia; bRiga Stradins University, Riga, Latvia


Background: Insulin resistance for adolescents with obesity takes up a central role in the development of metabolic comorbidities, especially of type 2 diabetes.

Objective and hypotheses: The aim of this study was to compare anthropometric data, apolipoprotein B, glucose, insulin level and HOMA-IR coefficien between genders.

Method: Data about anthropometric parameters, blood samples, 6-min walk test (6MWT), eating habits and physical activities was collected and analyzed by a multidisciplinary team in Children’s Clinical University Hospital (Riga, Latvia).

Results: 60 children participated in study, 25 girls and 35 boys. Mean age (years±S.D.) was 13.3±2.5, weight (kg±S.D.) 86.9±23.7, height (cm±S.D.) 165.9±12.4, BMI (kg/m2±S.D.) 31.1±5.2, waist circumference (cm±S.D.) 104.5±14.1. Analyzing possible gender differences in obesity-related complication development, there was found statistically significant higher waist circumference for boys (cm±S.D.) 113.5±19.19 compared to girls (cm±S.D.) 97.3±9.3 (P=0.037). Insulin level was statistically significant higher for boys (μU/mL±S.D.) 22.0±11.3 compared to girls 10.4±6.4 (P=0.014). Boys had statistically significant higher Apo B level in blood serum (mmol/l±S.D.) 1.0±0.2 compared to girls Apo B level 0.8±0.1 (P=0.049). Calculated HOMA-IR coefficient was (value±S.D.) 4.8±2.6 for boys and 2.3±1.7 for girls – significant gender differences was found (P=0.019).

Conclusion: It is possible that there is gender predisposition to obesity-related complication development. Further research should be done to extend the study population and to assess factors that may have had effect on the result (birth weight, duration of exclusive breastfeeding, negative family history) for boys and girls.

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