ESPE Abstracts (2016) 86 P-P2-776

Central Nervous System Abnormalities on Brain Magnetic Resonance Imaging Among 200 Korean Girls with Central Precocious Puberty

Shin-Hee Kim, Moon Bae Ahn, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Min Ho Jung & Byung-Kyu Suh


Department of Pediatrics, College of medicine, The Catholic University of Korea, Seoul, Republic of Korea


Background: Central precocious puberty (CPP) may result from organic lesions, but it is most frequently of idiopathic origin in girls.

Objective and hypotheses: The objective of the study was to identify central nervous system abnormalities in girls with CPP.

Method: This retrospective study was performed in 3-tertiary care hospitals between 2005 and 2015. During this period, 200 girls with CPP performed brain magnetic resonance imaging (MRI). Of the 200 girls, 12 (6.0%) were younger than 6 years, 188 (94%) were between 6 and 7 years. We analyzed the radiologic findings and evaluated related clinical and biochemical factors.

Results: Brain MRI showed no abnormalities in 183 (91.5%), abnormalities of the hypothalamic-pituitary area in 16 (8.0%), and tuber cinereum hamartoma in one girls (0.5%). Abnormalities of the hypothalamic-pituitary area included microadenoma (n=6), pituitary hypoplasia (n=5), Rathke’s pouch cyst (n=3) and cyst of pituitary pars intermedia (n=2). Three (25.0%) of 12 girls aged <6 years had abnormal brain MRI findings, whereas 14 (7.4%) of 188 girls aged 6–7 years had abnormal brain MRI findings (P=0.054). There were no significant differences in clinical and biochemical parameters between girls with abnormal brain MRI findings and those with normal findings.

Conclusion: A small, but not negligible proportions of girls with CPP have organic lesions, most of which are benign.

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