Background: Hashimoto thyroiditis (HT) is part of the spectrum of autoimmune thyroid diseases and is characterized by the destruction of thyroid cells by various cell- and antibody-mediated immune processes.
Objective and hypotheses: The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with HT.
Method: A total of 80 patients with positive anti-thyroid antibodies who were between 6-17.9 years of age were retrospectively studied. Age, gender, symptoms at the time of presentation, family history of thyroid disorders, clinical and laboratory findings were recorded. The levels of thyrotropin, free thyroxin thyroid autoantibodies (thyroid peroxidase and thyroglobulin antibodies), immunoglobulin A (IgA) anti-tissue transglutaminase antibodies (IgA-tTG) and thyroid ultrasound were enrolled.
Results: The study consisted of a population of 80 patients with 81.2% (65) girls and 18.8% (15) boys. Family history of thyroid disease was determined in 38 (47.5%) patients. The most common symptoms were goiter (30%) and weight gain (25%). Forty three (53.8%) patients presented with euthyroidism, while 23 (28.7%) and 14 (17.5%) patients with subclinical hypothyroidism and hypothyroidism, respectively. Thirty seven (46.2%) patients had goiter. IgA-tTG was positive in only one patient (1.25%) with HT. The symptoms of CD were present and small intestine biopsy revealed villous atrophy and crypt hyperplasia in this patient.
Conclusion: In our study, the major symptoms were goiter, weakness and weight gain and only one patient (1.25%) was found to have CD. This study has shown that the prevalence of CD in children with HT is higher than in the general population.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology