ESPE Abstracts (2016) 86 P-P2-425

Constitutional Delay of Puberty: Clinical and Hormonal Characteristics of Patients

Lubov Osipova, Oleg Latyshev, Lubov Samsonova, Goar Okminyan, Elena Kiseleva & Elvira Kasatkina


RMAPES, Moscow, Russia


Objective and hypotheses: To examine anthropometric, hormonal characteristics and their relationship in boys with constitutional delay of puberty (CDP).

Method: The study included 47 boys older 13.2 year old with CDP. It evaluated anthropometric indicators, bone age and hormonal status.

Results: The patients were divided: the first group consisted of 25.5% (12/47) of boys with pathological growth (Median/Me Ht-SDS=−2.3). Of them, a normal BMI was 83.4% (10/12), deficiency weight and obesity by 8.3% (1/12).The second group of patients with low normal growth (Me Ht-SDS=−1.6) was 32% (15/47). Of them, normal BMI was 47% (7/15), 40% (6/15) – a overweight/obesity and 13.3% (2/15) – a deficiency weight. The third group of patients with normal growth (Me Ht-SDS=−0.1) was 42.6% (20/47). Of them, overweight/obesity was 70% (14/20), 30% (6/20) – a normal BMI. The pathological delay of bone maturation in first group was 75% (9/12), in second group, 46% (7/13), in third group −18.8% (3/16). Overweight/obesity were encountered significantly more frequently in boys normal growth (P=0.04) than with pathology growth. The delay of bone maturation in patients with normal growth encountered less frequently than in patients with pathological growth (P=0.07). The hormonal characteristics was no differences between boys with the pathological and normal growth, such as inhibin B, AMH, LH, FSH, estradiol, cortisol, prolactin, IGF-1, insulin. In boys with normal growth, testosterone was lower (Me 1.2 vs 5.7 nmol/l, P=0.01), DHEAS was higher (6.1±2.5 vs 2.3±0.8 mcmol/l, P=0.012) than in boys with delayed growth.

Conclusion: The CDP in boys is heterogeneous and only in half the cases is accompanied by growth retardation. In contrast to boys with pathological growth, in boys with normal growth, CDP is associated with overweight/obesity, with a mean value of bone maturation, higher levels of DHEAS and lower levels of testosterone.

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