ESPE Abstracts (2016) 86 P-P2-63

The Evolution of Bone Age in Girls with Premature Adrenarche

Chrysanthi Marakaki, Sophia Theodoropoulou, Dimitrios T Papadimitriou, Eleni Dermitzaki & Anastasios Papadimitriou


Paediatric Encocrinology Unit, Third Department of Paediatics, University of Athens, “Attikon” University Hospital, Athens, Greece


Background: In premature adrenarche (PA) children bone age (BA) may be greater than chronological age (CA), however final height is usually within target height (TH).

Objective and hypotheses: Aim of the study was to evaluate the evolution of BA in girls with PA.

Method: We studied retrospectively the files of 60 girls with PA followed in our unit. Anthropometric data and Tanner pubertal status were determined in each visit and BA was evaluated in 12-month intervals. Predicted adult height (PAH), estimated at presentation and at last visit, was compared to TH.

Results: Mean follow-up time was 3.6 years. At presentation, mean age (S.D.) was 6.55 (1.0) years, Height SDS 0.868 (1.0), BMISDS was 1.23 (1.1) and BA was +1.13 (0.86) years greater than CA. 19/60 girls (31.7%) were obese (BMISDS>2). PAH at presentation was 0.454 SDS less, whereas at the last visit (3 years later) was 0.244 less than mean parental height (TH). We subdivided the PA girls, according to baseline ΔBA-CA, into three subgroups. Group 1 (ΔBA-CA <1 year) consisted of 21 girls (35%) with age at presentation 6.36 (1.17). BA increased from +0.36 (0.46) at baseline to +1.12 (0.75) years, at year 3, P<0,001. In Group 2 (ΔBA-CA >1 but <2 years) consisted of 30 (50%), mean age 6.49 (1.0), no statistical difference in BA evolution was noted. Group 3 (ΔBA-CA ≥2 years), consisted of nine girls (15%), mean age 7.18 (0.6), BA decreased from +2.49 (0.35) to +1.38 (0.59), at year 3, P<0.001.

Conclusion: The majority of PA girls present advanced BA. It seems that the norm for BA in PA girls is to be advanced by about one year. Girls with ΔBA-CA <1 year or ≥2 years are expected to present in the next 3 years after diagnosis, an increase or decrease in BA advancement, respectively. The evolution of BA resembles to the statistical phenomenon of regression to the mean, only that the mean is one year BA advancement. The latter could be attributed to the above average height of PA girls.

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