Background: Diagnosis of congenital adrenal hyperplasia (CAH) is delayed in developing countries and children are long exposed to high levels of androgens. These androgens have deleterious effect on heart.
Objective and hypotheses: Evaluate cardiac function of children followed for CAH and compared it to a group of healthy children.
Method: We carried out a case-control study, 1 case for 2 controls matched for age and genotypic sex, among children followed up for CAH in the single endocrinology unit of the Mother and Child Center of Chantal Biyas Foundation. Standard echocardiography measurements were done in time mode motion, two-dimensional and doppler. We analyzed the ejection fraction (LVEF), fractional shortening and left ventricular mass; output and cardiac index; E and A waves, E/A ratio; deceleration time and diameter of the left atrium; tricuspid annular plane systolic excursion.
Results: We included 19 patients with a median age of 6 years and 38 controls stackable distribution. One subject had dilated cardiomyopathy. LVEF ranged between 60 and 83%. Systolic function of two ventricles and diastolic of the left one were comparable in the two groups.
Conclusion: Excess androgens does not seem detrimental to the cardiac function in our study population.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology