ESPE Abstracts (2016) 86 P-P2-95

Early Adrenarche: A Common Query but not Easily Resolved

Ainhoa Sarasuaa & Ignacio Diez-Lopeza,b


aOSI Araba – University Hospital of Alava, Vitoria – Basque Country, Spain; bBasque Country University, Vitoria – Basque Country, Spain


Introduction: Early/advanced adrenarche is a frequent reason for consultation in Children Endocrinology.

Objectives: To evaluate the number and characteristics of cases of early/advanced adrenarche referred for assessment to the Children’s Consultation Endocrinology in the period between January 2015 and December 2015.

Results: In this period are rated 522 first consultations of which 39 (7%) have been prematurely adrenarche. In the 39 cases; 28 cases were girls (71%) and 11 children. 30 cases were born in Spain (76%) and 8 in Africa. In three cases there was a history of hyperandrogenism found in first-degree family. As for perinatal history three were born preterm with weight and suitable length and a case (born at term) was small for gestational age. The average age of consultation was 7 years 9 months (minimum 4 years 9 months) in girls and 8 years 4 months (minimum 5 years 9 months) in children. 64% (25/39) had a weight according to age. 11 were diagnosed of overweight and obesity three, the latter three had advancement of bone age of 2 or more years for chronological age. Bone age was according to their chronological age in 15 of the 39 cases. Study has been made of 17-OH progesterone, testosterone and DHEA-S in all cases with bone age advancement, resulting in normal range * values in all but one case with testosterone levels of 2.7 ng/dl and advancement of bone age 2.5 years (child finally diagnosed a Leydig cell tumor).

Conclusions: The results conform to the published literature; the highest incidence of early/advanced in girls in immigrant population and its relationship to overweight adrenarche. A closer contact with the Primary Care Pediatrics could provide those children with advanced bone age adrenarche and according to their chronological age were controlled by their Pediatrician thus avoiding unnecessary travel and consultations.

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