Background: Anti-Müllerian hormone (AMH) and inhibin B (INHB) are two hormones investigated as markers of ovarian reserve in female. serum AMH and INHB levels change through the progression of puberty, and might be markers for identifying pubertal progression rate in girls.
Objective and hypotheses: To invetigate serum AMH and INHB levels as markers of pubertal progression rate in girls with central precocious puberty (CPP).
Method: A total of 128 girls were enrolled, 65 with premature thelarche (PT) and 63 with CPP according to GnRH stimulation tests. serum AMH and INHB levels were also accessed in all the girls on the diagnosis. Girls with CPP underwent a six-month follow up for pubertal advancement, height acceleration, and bone-age maturation. Based on these criteria, the participants were assigned to two subgroups: progressive CPP (P-CPP) group (n=50) and slowly progressive CPP (SP-CPP) group (n=13). An additional 20 age-matched healthy girls were evaluated for AMH and INHB.
Results: AMH and INHB were potential markers for distinguishing P-CPP from SP-CPP. By comparison with SP-CPP group, girls with P-CPP had lower AMH (4.82 (1.9411.15) ng/ml vs 2.79 (1.046.16) ng/ml, P=0.0047) and higher INHB (56.94 (16.54123.60) pg/ml vs 27.61 (19.4667.48) pg/ml, P=0.1628). Based on receiver operating characteristics (ROC) analysis, the area under the curve (AUC) was 0.80 for AMH, 0.83 for INHB, and 0.88 for the combination of AMH and INHB. The combination of AMH and INHB (with cut-offs of 4.25 ng/ml and 31.35 pg/ml, respectively) results in 93% sensitivity and 71.5% specificity.
Conclusion: Our results suggest that serum AMH and INHB levels provide a reliable method that assist in the distinction between P-CPP and SP-CPP.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology