Rapidly accumulating epidemiologic and experimental evidence has indicated that insufficient sleep, such as commonly experienced in modern societies by all age groups, reduces insulin sensitivity and impairs glucose metabolism in healthy adults, and increases the risk of incident type 2 diabetes. Studies in type 1 or type 2 diabetic adults show a link between reduced sleep quality or duration and poor glyceamic control. While poor diabetes control may impair sleep due to nocturia, nocturnal hypoglycemia disrupting sleep and the need for night-time diabetes care, the fact that prospective studies show a relationship between insufficient sleep and the development or aggravation of existing type 1 or type 2 diabetes suggests the existence of an opposite direction of causality. Studies that examined the link between sleep and glyceamic control/glucose metabolism in pediatric populations are scarce. Nevertheless, similarly to adult studies, experimental and cohort studies have reported an association between short sleep and insulin resistance in healthy children/adolescents. No study used objective assessment of sleep to examine the link between habitual short/poor sleep and glyceamic control in type 1 diabetic children/adolescents. In this presentation, we will show preliminary results from an ongoing longitudinal study that uses both subjective and objective measures of sleep to delineate which sleep characteristics (quality, duration, regularity) best predicts glyceamic control in type 1 diabetic children and adolescents. The magnitude of the associations between sleep disturbances and glyceamic control in our sample suggests that intervention studies aiming to pay a sleep debt and/or improve sleep regularity may be clinically relevant.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology