Precocious puberty is defined by the development of secondary sexual characteristics before the age of 8 in girls and before the age of 9 in boys. If not diagnosed and treated at an early stage, precocious puberty can compromise final adult height and trigger psychological disturbances. Gonadotropin- releasing hormone analogs (GnRHa) contributes to achievement of target final height by reducing the acceleration of bone maturation.
Objectives: To analyze clinical and para clinical features in patients with precocious puberty, effect of triptoreline in improvement of secondary sexual characteristics and predicted adult height (PAH) after 12 months of treatment.
Subjects and Method: Case-series study included 79 patients with precocious puberty at Childrens Hospital 1 up to July 2016.
Results: After 12 months of Triptoreline treatment, secondary sexual characteristics reduced or ceased, acceleration of bone age decreased, sexual hormonal levels (FSH, LH, Estrogen/testosterone) fell below puberty range. We analyzed PAH of twenty-three female with initiation of treatment before the age of 8, PAH improve significantly before and after 12 months of treatment in this group 163.4±7.7 cm and 164.7±7.6 cm, respectively (P< 0.05).
Conclusions: Triptoreline decreases secondary sexual characteristics such as menarche, breast development, pubic hair, penis enlargement, acne, body odor and reduces the concentration of hormons (FSH, LH, Estradiol, Testosterone). In addition, Triptoreline increased PAH resulting in improving final adult height.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology