ESPE Abstracts (2018) 89 P-P3-361

Prevalence and Demographic Profile of Thyroid Disorders in Indian Children

Aashish Sethi, Smita Ramachandran & Inderpal Kochar

Indraprastha Apollo Hospital, Delhi, India

Introduction: Thyroid hormone abnormalities are the commonest endocrine disorder in India and also the commonest preventable cause of mental retardation.

Aim: To determine the prevalence, clinical profile, etiology and associated co-morbidities of thyroid dysfunction in children.

Materials and Methods: This is a retrospective study, performed in our tertiary care Pediatric Endocrine Center at Indraprastha Apollo Hospital, Delhi, India from patients’ record of 7 years from January 2011 to December 2017. All the patients referred to pediatric endocrine clinic with abnormal thyroid function test report were included in this analysis.

Results: Total of 522 (F:M=1.8:1) patients were referred with abnormal thyroid function test report, out of which 98 (18.77%) were diagnosed to have subclinical hypothyroidism, while 18 (3.44%) patients had hyperthyroidism. 6 patients had secondary hypothyroidism. Among the patients with hypothyroidism, most common presenting age was 12-13 years of age followed by 0-1 year of age, while commonest presenting feature was short stature (53.06%) followed by lethargy, constipation. The commonest etiology of hypothyroidism was found to be dyshormonogenesis. A host of co-morbidities was observed along with thyroid dysfunction. There were 4 patients with Turner syndrome, 10 with Downs syndrome.

Conclusion: Thyroid disorders can have a varied spectrum ranging from subclinical to hyperthyroidism. Apart from short stature a thyrid profile should be done in syndromic children for early diagnosis and treatment.

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