ESPE Abstracts (2018) 89 LB-P-5

Association between the Use of Antenatal Steroids for Lung Maturation and Hypoglycemia in Newborns Between 26 and 34 6/7 Weeks of Gestation

Gina Marcela Gonzalez Valenciaa,b, Jessica Lorena González Castañedaa, María Camila Velandia Avendañoa, Fabio Camilo Suarez Cadenaa, Eliana Rocío Arango Fontechaa, Andres Felipe Ochoa Diaza & Victor Clemente Medonza Rojasa,c

aIndustrial University of Santander, Bucaramanga, Colombia; bUniversity Hospital of Santander, Bucaramanga, Colombia; cIndustrial University of Santander - Pediatric Endocrinologist, Bucaramanga, Colombia

Objective: The aim of this study was to evaluate the difference between the incidence of hypoglycemia in those preterm newborns who were exposed to steroids and those who were not.

Methodology: This is a prospective cohort study of preterm infants born between 2017 and 2018 at a gestational age of 26 to 34 6/7 weeks in the Hospital Universitario de Santander- HUS- in Bucaramanga, Colombia.

Results: 128 preterm infants were evaluated. 111 (86.7%) had been exposed to antenatal steroids. The median maternal age was between 23 and 24 years of age for both those who were exposed and those who were not (P=0.190). The exposed vs unexposed maternal comorbidities were: preterm labor (70.6% vs 52.3; P=0.157), premature rupture of membranes (29.4% vs 27.9%; P=0.921), gestational diabetes (5.9% vs 7.2%; P=0.842), urinary tract infection (29.4% vs 18.0; P=0.270) and chorioamnionitis (11.8% vs 9.0%; P=0.717). Female sex patients were 47.1% vs 45.1% (P=0.927) respectively. The median gestational age was 33 weeks for both groups (P=0.216) and birth weight was 1640 vs 1945 g (P=0.190) respectively. The proportion of Apgar scores under seven at 5 minutes was 11.8% vs 5.4% (P=313). Median metabolic flux was similar among the two groups (6.17 vs 6.19 mg/kg per min, P=0.365). The incidence proportion of hypoglycemia during the first 48 hours of life was 29.4% in unexposed vs 24.3% in exposed (RR 0.827, IC95% 0.371–1.851; P=0.652), while incidence density of hypoglycemia was 8.80 and 6.30 cases per 1000 person-hour (HR 8.859 m IC95% 0.380–1.912; P=0.468), respectively.

Conclusion: There was no significant difference in the incidence of hypoglycemia among those who were exposed to antenatal corticosteroid for lung maturity and those who were not.