Objective: To observe and analyze the efficacy and safety of autologous stem cell transplantation (AHSCT) in children with type 1 diabetes.
Methods: Twelve children were enrolled in our study who were newly diagnosed as type 1 diabetes in Childrens Hospital of Fudan University from Sep 2009 to Dec 2011. Changes in the exogenous insulin requirement were observed and HbA1C and C peptide level were measured before and after AHSCT.
Results: After transplantation, insulin dependence was observed in 2/12 patients. Complete remission rates were 2/3, 1/2 and 1/4 after transplantation for 6, 24 and 48 months respectively. One child had a complete remission for almost 63 months. The level of HbA1C decreased significantly after transplantation (P=0.000). Meanwhile, the C peptide level enhanced a lot (P=0.004). However, no relationship was found between complete remission duration and other parameters, such as height, weight, BMI, DKA or not, HbA1C level, C peptide level before transplantation. No serious complication was observed during the whole phase.
Conclusions: Our data indicated that AHSCT has slight complication and could significantly improve β-cell function. Although AHSCT failed to cure type 1 diabetes, but it can prolong the remission period for new onset patients.
Keywords: hematopoietic stem cell, transplantation, type 1 diabetes, HbA1C, C-peptide
27 - 29 Sep 2018
European Society for Paediatric Endocrinology