Background: Insulin deficiency inhibits protein synthesis and stimulates protein degradation, and then amino acids metabolism could be altered in diabetes mellitus.
Objective: The aim of this study is to analyze amino acid plasma profile in a group of children with type 1 diabetes, and to evaluate its potential application as markers of metabolic control of the disease.
Subjects/Methods: A clinical assessment and metabolic study (amino acid plasma concentrations) was accomplished in a group of 49 children diagnosed with type 1 diabetes, aged 8.6 to 14.3 years, and a group of 48 healthy children (control group), aged 7.4 to 14.8 years.
Results: Plasma concentrations of ARG, GLN, ILE, PHE, THR, TYR, VAL and TAU were significantly higher (P<0.05) within the diabetic group with respect to the control group. Likewise, plasma concentrations of branched-chain (347.65±58.76 vs. 285.20±45.20 nmol/ml), glucogenic (1252.74±236.82 vs. 1053.69±211.19 nmol/ml) and ketogenic amino acids (441.62±57.09 vs. 354.13±53.45 nmol/ml) were significantly higher (P< 0.05) in the diabetic group with respect to the control group. There was no correlation between the single amino acid (or amino acids groups) plasma levels and the evolution of the disease (years) or Hb1Ac.
Conclusions: The study of changes in amino acid plasma profile in the young diabetic, probably as a consequence of insulinopenia, could have interest as a marker of metabolic control for the disease.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology