Background: Precocious puberty in girls may result in loss of FAH, and particularly may relates to obesity when entering adulthood. However,The influence of the timing of pubertal onset on the FAH and the change of body weight during pubertal stages is still controversial.
Objective: The research is to investigate the pubertal growth pattern and the change of BMI levels in girls with ICPP and those who have normal onset of puberty but at different ages.
Method: 23 girls with ICPP without interventions (entered puberty at age from 6 to 8 years) and 250 normal Cantonese schoolgirls (recruited at 7.24±0.38 years of age) were followed up annually until they reached FAH. ICPP girls defined as Group 1, and normal girls were subdivided into 4 groups according to the ages at the onset of puberty: group 2=89 years (N=69), group 3=910 years (N=82), group 4=1011 years (N=52), group 5=>11 years (N=47).
Results: • From Group 1 to 5, girls reached menarche at 10.59±1.36 years, 11.55±1.12 years, 12.19±1.17 years, 13.00±1.13 years, 13.58±0.83 years, respectively(P<0.001).
• Girls with early pubertal onset had longer duration from the onset of B2 to FAH (5.76±0.89 years, 4.31±0.74 years, 4.02±0.84 years, 3.69±0.60 years, 3.06±0.78 years in each group respectively, P<0.001), and had increased PHV (9.03±0.95 cm, 8.48±0.79 cm, 8.21±1.20 cm, 8.16±0.92 cm, 7.79±1.08 cm, P<0.001) as well as more total pubertal height gain (33.29±4.43 cm, 28.45±3.99 cm, 25.22±4.32 cm, 24.38±4.29 cm, 23.06±3.93 cm, P<0.001).
• No significant differences of FAH (158.61±7.40 cm, 157.60±6.25 cm, 158.13±5.28 cm, 159.58±5.74 cm, 159.95±6.11 cm, P=0.478) and FAHSDS (0.06±1.34, −0.17±1.35, −0.04±0.96, 0.26±1.04, 0.15±1.13, P=0.325) were found between groups.
• However, girls who enter puberty earlier had increased BMISDS levels both at age of onset of puberty (0.59±1.09, 0.55±1.26, 0.21±1.26, 0.14±1.11, −0.28±1.09, P=0.014) and at time when they reached FAH (0.30±1.11, 0.33±1.07, 0.09±1.21, −0.20±1.07, −0.29±1.19, P=0.001).
Conclusions: Pubertal growth pattern depends on the timing of the onset of puberty in girls. Girls who mature at early age but exhibit the compensatory pubertal development can achieve normal FAH, however, may exhibit increased body weight gain during puberty.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology