ESPE Abstracts (2018) 89 P-P2-250

Growth and Body Composition of Term Healthy Indian Infants from Birth to 2 Years of Age

Vandana Jaina, Brijesh Kumara & Anura Kurpadb


aAll India Institute of Medical Sciences, New Delhi, India; bSt. John’s Medical College, Bengaluru, India


Objective: To do longitudinal assessment of fat mass (FM)% of term, healthy Indian infants by stable isotope dilution method and skinfold thicknesses.

Methods: Term healthy singleton newborns, with birth weight between 1.8 to 4.0 Kg, were followed from birth to 2 years. Anthropometry and skinfold thickness measurement at biceps, triceps, subscapular and supra-iliac sites was done serially at 10 days, 3 months, 1 and 2 years. Anthropometric data was converted to z-scores using WHO Anthro software. Body composition was assessed by deuterium dilution method in a subset of infants at all these time points. FM% was also calculated from the sum of skinfolds using Weststrate and Deurenberg’s equations.

Results: 147 boys and 103 girls were enrolled. Anthropometry and FM% is summarized in Table. The median z-scores of weight, length as well as BMI were negative at all points, but showed gradual improvement. FM% measured by skinfold thickness and deuterium were significantly different from each other, and did not show any correlation. The difference was the greatest at 10 days and minimum at 3 months.

Table 1 Serial anthropometry and fat mass percentage.
Parameters10 days3 months1 year2 years
N250217223186
Age (Days)13±3102±14400±25743±32
Weight (Kg)3.0±0.55.6±0.89.0±1.311.0±1.4
Weight Z-score#−1.3 (−5.0 - 1.1)−1.2 (−4.7 - 1.8)−0.7 (−9.8 - 2.9)−0.9 (-3.2 - 2.5)
<−2*60 (24.0)38 (17.5)24 (10.8)22 (11.8)
Length (cm) 50.5±2.361.0±3.175.2±3.184.6±3.2
Length Z-score#−0.6 (−4.6 - 3.2)−0.2 (−3.9 - 3.3)−0.5 (−4.1 - 3.0)−0.9 (−3.8 - 1.6)
<−2*35 (14.0)23 (10.6)19 (8.5)18 (9.6)
BMI11.9±1.515.0±1.815.9±1.815.3±1.6
BMI Z-score#−1.5 (−5.6 - 3.2)−1.3 (−5.6 - 2.2)−0.7 (−12.9 - 2.9)−0.5 (−3.6 - 3.9)
<−2*69 (27.6)62 (28.6)20 (9.0)16 (8.6)
FM% from skinfold thicknesses16.9±3.624.0±3.121.7±3.220.1±2.9
FM% by deuterium dilution11.5±7.221.2±7.617.7±8.325.7±10.1
(N)(129)(163)(70)(82)
*N (%),# Median (range)

Conclusion: FM% of term Indian infants by deuterium dilution technique is 11.5±7.2% at birth, nearly doubles by 3 months, and then remains relatively stable till 2 years. It is not correlated with skinfold thickness derived FM%.

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