Atopic dermatitis (AD) is a chronic inflammatory disease affecting children and adolescence. The traditional therapeutic options for AD, including emollients topically and immune modulatory agents systemically focusing on reducing skin inflammation and restoring the function of the epidermal barrier, are proven ineffective in many cases. Several studies have linked vitamin D supplementation with either a decreased risk to develop AD or a clinical improvement of the symptoms of AD patients. In this report we present a girl with severe AD who - under adequate supplementation with cholecalciferol, was treated with calcitriol and subsequently with paricalcitol. She had significant improvement almost healing of her skin lesions within 2 months, a result sustained for 3 years now. Because of hypercalciuria as a side effect from calcitriol therapy, therapy was continued with paricalcitol, a Vitamin D analogue used in secondary hyperparathyroidism in chronic kidney disease. Calcitriol therapy may be considered as a safe and efficacious treatment option for patients with severe AD, particularly for those with refractory AD, under monitoring for possible side effects. Treatment with paricalcitol resolves hypercalciuria, is safe and should be further investigated as an alternative treatment of atopic dermatitis and possibly other diseases of autoimmune origin.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology