Objective: To evaluate bone mineral density (BMD) and its relationship with vitamin D in children with obesity.
Methods: We examined 110 children in the University Hospital (Minsk) from 2015 to 2018 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Body composition with evaluating of mineral component were made by dual energy X-ray absorptiometry with the calculation of feet, hands, spine, ribs, hips BMD (g/cm2), Z-test. The levels of vitamin D were determined. All children were divided into 2 groups: group 1 - children with obesity (n=75, boys(B)/girls(G)=47/28, age 14.24±2.02 yrs, BMI 32.7±5.3 kg/m2; group 2 normal-weight control (n=35, B/G=17/18, 14.08±2.47 yrs (P=0.3), 19.4±2.4 kg/m2 (P=0.0001)).
Results: Legs BMD were increased in boys with obesity (0.94±0.11g/cm2 vs 1.13±0.17g/cm2 (P=0.03)) compared to control group without significant differences in G (1.29±0.12g/cm2 vs 1.23±0.02 g/cm2 (P=0.5). Ribs BMD were higher in group 1 children compared to group 2 (B 0.72±0.08 g/cm2 vs 0.59±0.06 g/cm2 (P=0.02); G 0.71±0.05 g/cm2 vs 0.65±0.06 g/cm2 (P=0.05)). There were no significant differences in spine BMD (G 1.09±0.11 g/cm2 vs 0.98±0.14 g/cm2 (P=0.084), B 1.0±0.11 g/cm2 vs 0.87±0.24 g/cm2 (P=0.39)); pelvis (G 1.22±0.13 g/cm2 vs 0.98±0.14 g/cm2 (P=0.12); B 1.19±0.15 g/cm2 vs 1.04±0.21 g/cm2 (P=0.09)); total (G 1.18±0.09 g/cm2 vs 1.11±0.13 g/cm2 (P=0.29); B 1.17±0.13 g/cm2 vs 1.06±0.14 g/cm2 (P=0.21)) in obese children compared to control. A significant decrease in vitamin D levels were in obese B compared to control (29.48±4.7 ng/ml vs 33.41±2.1 ng/ml (P=0.05)); G (24.59±5.7 vs 34.41±3.2 ng/ml (P=0.04)).
Conclusions: A significant increase in ribs and legs BMD and decrease in vitamin D levels were found in children with obesity.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology