Introduction and aim: Metabolic bone disorders due to calsium and vitamin D deficiency are one of the most frequent extraintestinal symptoms in Celiac disease. In this study it is aimed to evaluate bone mineral density in patients with Celiac disease during diagnose and evaluate the factors related to bone mineral metabolism.
Material and Method: The study included 43 children diagnosed as Celiac disease between December 2015 and December 2017. Clinical, anthropometric, patological and laboratory (calsiyum, phosphor, alkalenphosphataz (ALP), parathormon (PTH), 25OHvitamin D levels) properties of patients were detected retrospectively. Lumbal (L1-L4) bone mineral density levels measured via DEXA (Dual Energy X-Ray Absorptiometry) were evaluated and Z scores due to cronological age and height age were calculated.
Results: Mean age of 43 patients (34 girl/9 boys) was 9.9±4.8 (2.517.7) years. 46.5% of patients were pubertal during diagnose. 30.2% (n=13) was 06 years old, 30.2% (n=13) was 711 years and 39.5% (n=17) was over 11 years. BMD Z score due to chronological age was −0.83±1.1 (−3.61.6) and −0.18±1.1 (−3.61.8) due to height age. There were no difference in BMD Z scores due to chronological and height ages (P=0.150, P=0.225, respectively). BMD Z scores due to chronological age was >−1 in 51.2% of the patients (n=22), between −1 and −2 in 34.9% (n=15) and <−2 in 14% (n=6). BMD Z scores due to chronological age <−2 in over 11 age was statistically high (P<0.001). Mean vitamin D level was 13.5±7.7 (4.635.1) ng/ml and no relation between BMD Z scores and plasma vitamin D, Ca, P, ALP and PTH levels (P>0.050). There was positive correlation between BMD Z scores due to chronological age and body weight, height and BMI Z scores (P<0.001, P=0.005, P=0.015, respectively).
Conclusion: Higher diagnose ages effects bone mineral density negatively in Celiac disease. Diagnose in early ages decreases bone mineral leak and decreases morbidity in patients with osteopeni and osteoporosis via treatment posibilities.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology