Background: Type 1 diabetes mellitus (T1DM) - related hepatopathy is not uncommon and tends to be more prevalent among children with poor glycemic control. Recent studies suggest that fatty liver disease may be more common in T1DM than previously thought.
Aim: The aim of this work was to determine the frequency of hepatopathy in patients with type 1 diabetes mellitus attended diabetes clinic at Alexandria university childrens hospital (AUCH) and its relation to the state of glycemic control and lipid profile.
Methods: Study was carried out on 70 patients diagnosed with type 1 diabetes mellitus attended diabetes clinic at AUCH. All were subjected to the following: History, full detailed physical examination, Anthropometric measurements: Height standard deviation (SD) score and body mass index (BMI) percentile were calculated using Centers for Disease Control (CDC) 2000 growth charts, Liver enzymes (ALT&AST), Liver function tests (albumin and prothrombin time), Lipid profile: total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides, HbA1C and transabdominal ultrasonography by using scoring system for detection of fatty infiltration of the liver.
Results: In the present study, the mean duration of diabetes was 6.5±2.2 years. About (51.4%) of the patients were using premixed insulin therapy. Hypercholestremia, hypertriglyceridemia, high LDL and low HDL were found in (24.3%, 17.1%, 8.6% and 4.3%) of the patients 8respectively. (62.9%) of patients were with poor glycemic control. More than half of the patients had been found to have fatty liver (52.9%).
Conclusion: A high rate of fatty liver among the patients was found and it was related to patients with poor glycemic control.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology