Objective: There have been very few studies, with contradictory results, on the serum trace elements in children and adolescents presenting with diabetic ketosis and diabetic ketoacidosis due to type-1 diabetes mellitus. The objective of this longitudinal controlled study was to determine serum trace element status including selenium (Se), zinc (Zn), copper (Cu), manganese (Mn), chrome (Cr), and cobalt (Co) in type-1 diabetic children and adolescents presenting with diabetic ketosis and diabetic ketoacidosis and to compare them with that of healthy controls.
Materials and methods: Thirty eight children and adolescents with diabetic ketosis and diabetic ketoacidosis, aged 3 to 17 years, and 38 similar ages - and the same sex-matched healthy controls were participated in the study. Serum hemoglobin A1c, free thyroxine (FT4), thyroid stimulating hormone (TSH), creatine kinase (CK), and trace elements including Se, Zn, Cu, Mn, Cr, and Co were measured. Blood gases were determined and whole blood analysis was performed. All patients were evaluated at the diagnosis (visit 1), 1015 days after diagnosis (visit 2), three months after diagnosis (visit 3), and six months after diagnosis (visit 4).
Results: The mean serum Se and Zn concentrations in diabetic patients at each visit were higher than those in healthy controls. No correlations were found between the serum Se and Zn levels and others parameters.
Conclusion: The serum Se and Zn levels of diabetic children and adolescents during six months after diagnosis are noticeably higher compared to those of healthy controls. Long term prospective and controlled studies are necassary.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology