ESPE Abstracts (2018) 89 P-P3-109

Clinical Profile and Outcome of Diabetic Ketoacidosis in a Tertiary Care Teaching Hospital of a Developing Country

Meghna Chawla, Tushar Deshpande & MK Behera

Smt Kashibai Navale Medical College and General Hospital, Pune, India

Objectives: Diabetic Ketoacidosis (DKA) is a dreaded complication and due to a paucity of studies on Paediatric DKA from India, we studied its clinical profile and outcome over the last 03 years.

Methods: A retrospective chart review was used to obtain demographics, clinical presentation and various laboratory parameters on presentation of DKA in children less than 12 years of age.

Results: See Tables 1–3.

Table 1 Demographic parameters of study cases (n=20)
DKA in New–Onset DM (n=11)DKA in Diagnosed DM (n=9)All DKA cases (n=20)
VariablesMean (95%CI of Mean), OR n (%)Mean (95%CI of Mean), OR n (%)Mean (95%CI of Mean), OR n (%)P-value
Age (years)8.5 (6.8–10.2)9.2 (6.8–11.5)8.8 (7.5–10.1)0.616NS
Age Groups (years)5–10 years7 (63.6)4 (44.4)11 (55.0)0.653NS
10–12 years4 (36.4)5 (55.6)9 (45.0)
Male Sex6 (54.5)1 (11.1)7 (35.0)0.070NS
AnthropometryHeight (cm)122.6 (112.7–132.6)121.2 (113.6–128.8)122.0 (116.1–127.9)0.810NS
Weight (kg)20.3 (16.7–23.9)19.2 (16.3–22.0)19.8 (17.6–21.9)0.597NS
BMI (kg/m2)13.7 (11.2–16.1)12.9 (12.3–13.6)13.3 (12.1–14.6)0.568NS
Table 2 The clinical outcome of study cases (n=20)
GlycaemiaBlood Glucose (mg%)542.4 (468.6–616.1)537.4 (490.9–583.9)540.1 (498.6–581.7)0.906NS
HbA1C (%)12.6 (11.7–13.6)12.2 (11.3–13.1)12.4 (11.8–13.0)0.460NS
Urine KetonesModerate3 (27.3)5 (55.6)8 (40.0)0.343NS
Severe7 (63.6)4 (44.4)11 (55.0)
Highly Severe1 (9.1)01 (5.0)
pH7.15 (7.05–7.25)7.19 (7.14–7.25)7.17 (7.11–7.22)0.390NS
HCO39.0 (6.3–11.7)10.5 (8.5–12.5)9.7 (8.1–11.3)0.358NS
Sodium140.1 (135.0–145.2)137.8 (133.7–141.9)139.0 (135.9–142.1)0.450NS
Potassium4.2 (3.7–4.8)4.7 (3.8–5.7)4.5 (3.9–4.9)0.292NS
Chloride105.4 (100.9–109.9)106.4 (101.4–111.5)105.8 (102.8–108.9)0.720NS
Time for resolution31.6 (24.8–38.5)18.4 (13.9–22.9)25.7 (20.7–30.7)0.003**
Table 3 Associated complications
UTI03 (33.3)3 (15.0)0.206NS
Pneumonia1 (9.1)1 (9.1)2 (10.0)
Cerebral edema2 (18.2)02 (10.0)
Other01 (9.1)1 (5.0)
NS Statistically not significant

Conclusions: The mean age, sex and anthropometric parameters did not differ significantly. Laboratory parameters or the incidence of complications also did not differ significantly. However, the mean time of resolution is significantly higher in the new-onset group (P-value<0.01).

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