ESPE Abstracts (2018) 89 P-P3-111

Type 1 Diabetes and Central Precocious Puberty a Rare Association

Mimouna Bessahraoui, Nassima Oussaleh, Sidi Mohamed Azzouz & Radia Rezak


University of Medecine, Oran, Algeria


Introduction: In girls, precocious puberty is defined as the sign of secondary sexual characteristics occurring before the age of 8 years in Caucasian girls. Type 1 diabetes (T1D) is a rare association with precocious puberty. We discuss through this case, the involvement of type 1 diabetes mellitus in the onset of early puberty from a review of the literature.

Observation: We report the case of precocious puberty in a 6-year-old girl followed for T1D since the age of 3.5 years, the T1D was well-balanced under insulinotherapy. At the age of 6 years, the child presented signs of precocious puberty. Clinical examination revealed a Tanner stage III for breast development and Tanner stage III for pubic hair development with statural advance of more than 2 S.D. The LHRH test was for central precocious puberty, and brain MRI had no abnormal lesion or tumor posing the diagnostic of central precocious puberty. Under LHRH analogues,we noted a regression of bilateral mammary hypertrophy, the standardization of the speed of growth and regression of signs of estrogenic impregnation on pelvic ultrasound

Conclusion: Precocious puberty and type 1 diabetes is rare association. The relationship between these two pathologies has not been determined.

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