Background: Type 1 Diabetes Mellitus children are at risk to suffer from thyroid dysfunction. The association between thyroid stimulating hormone and hemoglobin A1c is still controversy.
Objective: To determine the association between thyroid stimulating hormone and hemoglobin A1c in type 1 Diabetes Mellitus children.
Methods: We conducted a cross sectional study from January - June 2017 in pediatric endocrine outpatient clinic dr Soetomo Hospital. Subjects were Type 1 DM children aged 7 until <18 years old. Exclusion criterias were diabetes ketoasidosis, previously diagnosed thyroid problems and patients hospitalized in PICU.
Results: 34 patients included in the study. Nineteen (54.3%) were male, mean of age was 11.3 years old. Mean of duration of diabetes was 3 years, mean of thyroid stimulating hormone was 3.76 mIU/l. The lowest was 0.033 mlU/l and highest 45,300 mlU/l. There were 2 male patients with high TSH level, 25 and 45 mIU/l respectively. These patients then follow up for FT4 and we have normal FT4. So we diagnose patients as subclinical hypothyroidism. The association of duration of diabetes and Thyroid stimulating hormone was rs=−0.068; P=0.703 (P>0.05). The association of thyroid stimulating hormone and hemoglobin A1c was rs=−0.017; P=0,925 (P>0,05).
Conclusion: There was not any association between thyroid stimulating hormone and hemoglobin A1c in T1DM children.
Keywords: thyroid stimulating hormone, hemoglobin A1c, type 1 diabetes mellitus children.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology