Introduction: Hepatic steatosis(HS) is a frequent finding in obese children. Insulin resistance, hypertriglyceridemia and abdominal circumference (AC) are known risk factors, similar to Metabolic Syndrome (MS), but the precise pathophysyology remains unexplained.
Objectives: To analyze the prevalence of HS as identified by ultrasound as well as acanthosis Nigricans (AN) in two groups of obese patients; with or without presence of MS; by studying anthropometric, analytical characteristics and waist-length-ratio (WLR).
Material and methods: In this descriptive cross-sectional study, 190 children aged 514 with BMI>2SD where evaluated. Those patients with secondary causes of obesity have been excluded as HS due to other causes. We analyze somatometry, biochemical parameters (glucose, insulin, lipid profile, hepatic transaminases, HOMA, uric acid), as well as the presence or absence of acanthosis nigricans (AN) in both groups. Liver ultrasound was performed to define the presence or absence of steatosis and we have followed the classification IDF, to define the presence of MS in patients older than 11 years of age. All patients underwent an oral glucose tolerance test (OGTT). The statistical analysis was performed in SPSS 17.
Results: The cohort of 190 patients was equally weighted with respect to sex. The prevalence of HS was 36.8% (60% males vs 40% women). Metabolic criteria of MS are presented in the 36% (n=25) of patients with HS vs 11% without HS (n=13). There is positive correlation (R=0.78) between patients with metabolic syndrome and hepatic steatosis (P<0.05).
|SD OF BMI||4.6||3.1||P<0.05|
|WAIST LENGTH RATIO||0.78+/−0.1||0.55+/−0.2||P<0.05|
Conclusions: The prevalence of HS in our population is higher than previously published. Our results show that HS is related to BMI, AC, hypertriglyceridemia and HOMA index. We observed higher waist-length ratio in the population with HS and a higher incidence of MS. AN is also more prevalent in those patients with HS.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology