ESPE Abstracts (2018) 89 P-P3-149

The Effect of Vitamin D Supplementation on Metabolic Syndrome Parameters in Overweight and Obese Children and Adolescents in Greece

Christos Giannios, Nicolas Nicolaides, Ioanna Farakla, Georgios Papadopoulos, Sofia Gennitsaridi, Sofia Karampatsou, Gerasimos Kolaitis, George Chrousos & Evangelia Charmandari


Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece


Background: Accumulating evidence suggests that decreased 25-hydroxyvitamin [25(OH)D] concentrations are associated with components of the metabolic syndrome.

Objective: The aim of our study was to investigate the effect of vitamin D supplementation on metabolic syndrome parameters in obese children and adolescents.

Patients and methods: Two hundred thirty two (n=232) obese children and adolescents aged [mean ±S.D.)] 10.24±2.50 years were studied prospectively for one year. Subjects were randomly assigned to either the intervention (n=117) or the control group (n=115). Participants in the intervention group received 50,000 IU vitamin D weekly for 6 weeks and were subsequently placed on maintenance dose. Blood samples for determination of 25(OH)D, bone profile, liver function and cardiometabolic parameters were obtained at baseline and 12 months later. Systolic and diastolic blood pressure were determined twice and the mean was calculated.

Results: Overall, 220 eligible children and adolescents completed the study (109 in the intervention group and 111 in the control group). A significant decrease was noted in the BMI (P=0.001) over the study period, with the intervention group demonstrating significantly lower BMI compared with placebo group (P=0.016). Moreover, the intervention group had significantly lower fat mass (P=0.007) and higher HDL concentrations (P<0.05) compared with the placebo group. No significant differences were noted between groups over the study period in relation to arterial blood pressure, HbA1c (%), HOMA-IR and QUICKI.

Conclusions: Vitamin D supplementation may have beneficial effects on alleviating certain complications of childhood obesity.