The prevalence of metabolic syndrome (MetS) in young population continues to rise. Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to determine whether these adipokines are significant markers in defining MetS in pediatric population and to assess the effect of hypocaloric diet and physical activity on serum concentrations of adiponectine, leptin, and high sensitivity CRP (hs-CRP).
Material and methods: A prospective study was conducted over a period of 1 year, between January 2016 and December 2016, on 66 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timişoara. The patients diagnosed with MetS were put on diet and physical exercise for 3 months. Results: MetS was present in 63.6% of obese children. There was a significant and positive correlation between MetS and both leptin and hs-CRP, and a significant, negative correlation between MetS and adiponectin. After diet and physical activity three patients no longer met the criteria for MetS. Leptin, adiponectin and hs-CRP concentrations statistically improved after a three-month diet and physical activity program.
Conclusions: hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in pediatric population. Diet and physical activity have an impact on the metabolic status.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology