ESPE Abstracts (2018) 89 P-P3-209

Vitamin D Status in Children with Isolated Idiopathic GH Deficiency (GHD) in North and Central Greece

Kyriaki Tsiroukidoua, Maria Xatzipsaltib, Iliana Mamekaa, Ioulia Polychronib, Anastasios Vamvakisa, Maria Papagiannia & Lela Stamogiannoub


aEndocrine Unit, 3rd Pediatric Department, Aristotle University of Thessaloniki, Hippokrateion Hospital of Thessaloniki, Thessaloniki, Greece; bFirst Department of Pediatrics, P. & A. Kyriakou Children’s Hospital, Athens, Greece


Background: Vitamin D status in children with isolated GHD has been analyzed in few studies with controversial results. The aim of the study was to assess vitamin D status in children with idiopathic GHD in North and Central Greece.

Materials and methods: 128 children (M/F: 76/61, mean age 9.5 (S.D.±3.5 years) with isolated GHD were compared with 65 controls (M/F: 46/3, mean age 9.3 (S.D.±3.2 years). Children were divided into four groups according to the season of evaluation: the winter (December–Febuary: 44 children), the summer (June–August: 51 children), the spring (March–May: 59 children) and the autumn group (September–November: 26 children). Height, weight, BMI and BMI z-score were evaluated at the time of 25(OH)D3 serum levels measurement. Serum 25(OH)D3 levels <30 ng/ml and 20 ng/ml were defined as vitamin D insufficiency and deficiency, respectively.

Results: 79 children (36.9%) were vitamin D insufficient, 70 (32.7%) deficient and only 44 (20.6%) were between normal range. Lower vitamin D levels were found in the winter group than in the summer group (20.8±6.42 vs 27.11±11.97 ng/ml; P=0.004). No difference was found in vitamin D status between GHD children and controls. No difference was also found in VitD levels between GHD children from North and Central Greece (23.3±8.8 vs 25.5±11.64 ng/ml; P=0.35) despite the season of evaluation. No correlation between vitamin D, BMI z-score and GH max levels was also found.

Conclusions: Our data demonstrated a very high prevalence of hypovitaminosis D in Greek GHD children, regardless the region. Vitamin D status in children with idiopathic GH deficiency was similar to healthy children. Vitamin D assessment should therefore be considered routinely in GHD children even at sunny Mediterranean countries.

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