Objective: To evaluate the effect of Ziyin Xiehuo granules (ZYXH) and Zishen Qinggan granules (ZQ7G) on partial precocious puberty (PPP).
Methods: The present study was a multicenter, randomized, single-blinded, positive-controlled trial. A total of 143 patients were assigned to either the ZYXH group or the ZQ7G group using a random number table. The ZYXH group received ZYXH three times daily for 6 months, while the ZQ7G group received ZQ7G three times daily for 6 months. The diameter of the mammary nucleus, the results of uterus, ovarian, and maximum follicle, and Chinese medicine syndrome scores were collected at baseline, 3-month and 6-month of treatment.
Results: After 3-month treatment, there were no significant differences between the two groups in terms of the mammary nucleus index changes (left 3.44±3.09 vs. 3.51±3.07, P=0.790; right 3.05±2.87 vs. 3.60±2.97, P=0.719). The uterine volume in the ZYXH group was smaller than that in the ZQ7G group (2.06±1.57 vs. 2.58±2.23, P=0.006). Between the two groups, the differences of ovarian volume and maximum follicular diameter were not significant on either side (ovarian volume: left 1.23±0.68 vs. 1.30±0.64, P=0.809; right 1.25±0.66 vs. 1.37±1.12, P=0.984; maximum follicular diameter: left 3.87±1.72 vs. 3.52±2.17, P=0.158; right 3.55±1.69 vs. 3.90±2.10, P=0.314).
Conclusion: ZYXH granules and ZQ7G granules both affect the size of the mammary nucleus in girls with PPP, as well as Chinese medicine syndromes, with ZYXH granules displaying slight advantages over ZQ7G granules in terms of the decrease in the size of the uterus, ovaries, and ovarian follicles.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology