ESPE Abstracts (2018) 89 P-P3-373

Hypovitaminosis D and Chronic Autoimmune Thyroiditis Mammary Echostructural Involvements in Puberty

Seila Ibadula & Eduard Circo


Endocrinology Department, ‘Ovidius’ University, Constanta, Romania


Introduction: Benign breast pathology has a frequent onset during puberty-adolescence.

Objectives: Differential evaluation of breast echostructure in puberty stage III/V, on Tanner scale, depending on the presence of thyroid autoimmunity and hypovitaminosis D.

Method: Assessment of BIRADS score from 2 to 4 in three groups of girls associating premenstrual mastodynia: Group 1 - including patients with chronic autoimmune thyroiditis and normal vitamin D values; Group 2 - patients without thyroid pathology with moderate and severe vitamin D deficiency; Group 3 - patients with chronic autoimmune thyroiditis and moderate to severe vitamin D deficiency.

Results: The BIRADS 4 score was statistically significant (P <0.001) in the group with chronic autoimmune thyroid disease and among those with hypovitaminosis D. The intensity of the BI-RADS score was significantly (P <0.001) in favor of elevated serum levels of antithyroglobulin antibodies compared to antimicrosomal antibodies.

Conclusions: Mammary echostructural changes with pubertal onset may be correlated to thyroid autoantibodies and hypovitaminosis D by a mechanism that requires ascertainment.

Keywords: chronic autoimmune thyroiditis, hypovitaminosis D, benign mastopathy.

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