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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Poster Category 1

Thyroid (1)

hrp0092p1-283 | Thyroid (1) | ESPE2019

Children with Hashimoto's Thyroiditis have Increased Intestinal Permeability: Results of a Pilot Study

Aydin Banu Kucukemre , Yildiz Melek , Akgun Abdurrahman , Dogan Beyza Belde , Topal Neval , Onal Hasan

Background: Both genetic and environmental factors serve as the trigger of Hashimoto's thyroiditis (HT), but the exact mechanisms are still not fully understood. Increased intestinal permeability was shown to be a constant and early feature of several autoimmune disorders. Although HT is the most common autoimmune disorder worldwide, the role of intestinal permeability in its pathogenesis had received little attention. Human zonulin modulates intracellular...

hrp0092p1-284 | Thyroid (1) | ESPE2019

Different Endocrine Affects in DICER-1 Syndrome

Yilmaz Aslihan Arasli , Aycan Zehra , Erdeve Senay Savas , Çetinkaya Semra

Introduction: DICER1 syndrome is a pleotropic, autosomal dominant familial genetic tumor predisposition syndrome. DICER1 somatic + germ-line mutations (double hit hypothesis); cystic nephroma; pleuropulmonerblastoma, ovarian sex cord-stromal tumors, multinodular goitre (MNG) are associated with many conditions such as differentiated thyroid cancer, pituitary blastoma. We presented three cases, two of whom were siblings, who had been consulted because of no...

hrp0092p1-285 | Thyroid (1) | ESPE2019

Evaluation of Thyroid Function Tests in Children with Chronic Liver Diseases

Ön S.Sebnem , Acar Sezer , Demir Korcan , Abaci Ayhan , Öztürk Yesim , Çelik Sinem Kahveci , Böber Ece

Backgrounds/Aims: Studies related to changes in thyroid hormone metabolism in the course of chronic liver diseases have been conducted mostly in adults. In this study, we aimed to investigate the thyroid dysfunction in childhood chronic liver diseases.Methods: Between 2005 and 2018, 960 chronic liver disease patient file that followed in our gastroenterology department are reviewed. Among all study subjects, 107 (53 fema...

hrp0092p1-286 | Thyroid (1) | ESPE2019

Identification of a THRA Mutation in a 2yr Old Child with Clinical Features of Hypothyroidism and Multisystem Involvement

Sakremath Rajesh , Moran Carla , Lyons Greta , Boelaert Kristien , Chatterjee Krishna , Mohamed Zainaba , Rajanayagam Odelia

Background: Thyroid hormones act via receptors (TRα; TRβ) encoded by separate genes (THRA, THRB). Mutations in THRA are a recently-recognised cause of Resistance to Thyroid Hormone alpha (RTHα), a disorder with tissue-specific hypothyroidism but near-normal thyroid function tests.Aim: We describe the youngest recorded case of RTHa, in a 2yr old boy with disproportionate short stature, ...

hrp0092p1-287 | Thyroid (1) | ESPE2019

The Comparison of Natural Course Thyroid Autoimmunity in Children and Adults with Type 1 Diabetes: From the Diabetes Onset Up to Five Years of its Duration

Niechcial Elzbieta , Frontczak Anita Rogowicz- , Pilacinski Stanislaw , Fichna Piotr , Zozulinska-Ziólkiewicz Dorota

Introduction: Individuals with type 1 diabetes (T1D) are at higher risk of developing other autoimmune disease, including autoimmune thyroid diseases (AITD). The incidence of Hashimoto among people with T1D varies between 8 and 50%, depending on gender, age and ethnicity.Aim: To evaluate prevalence of anti-thyroid peroxidase (anti-TPO) and its correlation to the presence of thyroid dysfunction in children and adults ...

hrp0092p1-288 | Thyroid (1) | ESPE2019

Outcomes of Persistent Hyperthyrotropinaemia in Well Term Infants

Ng Sze , Katkat Nancy , Oryan Tal , Ayoade Kayode , Aleem Mahreen

Background: Neonatal hyperthyrotropinaemia (HT) is defined by elevated thyroid stimulating hormone (TSH) and normal free-thyroxine (FT4) level. Persistent HT in the neonatal period is often a diagnostic dilemma for clinicians to either treat to prevent subclinical hypothyroidism or to wait and monitor thyroid function tests (TFTs).Methods: As part of an audit, 1,449 term infants who had TFTs undertaken as part of a prolo...

hrp0092p1-289 | Thyroid (1) | ESPE2019

Thyroid Peroxidase Antibodies in Children with HLA-Conferred Susceptibility to Type 1 Diabetes

Saare Liisa , Peet Aleksandr , Tillmann Vallo

Introduction: The prevalence of thyroid peroxidase antibody (anti-TPO) positivity is estimated to be around 3-4% in healthy children and is remarkably higher in children with type 1 diabetes (T1D). However, anti-TPO positivity in children with HLA-conferred susceptibility to T1D who are not yet diagnosed with T1D, is not well studied. The aim of this study was to describe the prevalence of positive anti-TPO and its effect of thyroid function in children wi...

hrp0092p1-290 | Thyroid (1) | ESPE2019

Prediction of Permanent and Transient Congenital Hypothyroidism Based on Levothyroxine Dosages in Long-Term Follow-Up Patients: A Multicenter Retrospective Study in Japan

Higuchi Shinji , Itonaga Tomoyo , Shimura Kazuhiro , Nagasaki Keisuke , Satoh Mari , Takubo Noriyuki , Takahashi Ikuko , Sawada Hirotake , Hasegawa Yukihiro

Background: Congenital hypothyroidism (CH) can be categorized into two types: transient CH (group T) and permanent CH (group P). Several studies have recently demonstrated that the levothyroxine (LT4) dosage is useful for predicting LT4 requirement; however, none of the studies followed up their patients to puberty.Objective: To determine the cutoff value for the LT4 dosage as a predictor of LT4 requirement after puberty...

hrp0092p1-291 | Thyroid (1) | ESPE2019

An Incidental Finding of Thyroid Hormone Resistance Due to a De Novo Mutation in the THRB Gene

Averbuch Noa Shefer , França Monica , Lazar Liora , Tenenbaum Ariel , Phillip Moshe , de Vries Liat

Background: Thyroid hormone resistance (THR) is a rare genetic disorder that may be caused by thyroid hormone (TH) cell transporter defects or metabolism defects, but most cases are caused by an inherited mutation in the TH receptor beta (THRB) gene. The reduced responsiveness of target tissues to TH is characterized by elevated TH and a normal or elevated thyroid-stimulating hormone (TSH) level. Differentiating between THR and TSH-producing pituitary...

hrp0092p1-292 | Thyroid (1) | ESPE2019

Outcome of Congenital Hypothyroidism in Algeria: The Urgent Need to Implement a National Newborn Screening Program

Adel Djermane , Asmahane Ladjouze , Yasmine Ouarezki , Ourida Taleb Nessma , Kafia Zichi , Samira Aggoune , Bouzerar Zahir , Hachemi Maouche

Background: Congenital hypothyroidism (CH) is the commonest congenital endocrine disorder and the primary cause of treatable mental retardation. In low-income countries lacking newborn screening programs, CH remains a serious public health problem.Objective: To investigate the characteristics at diagnosis and clinical outcome of patients with CH in Algeria; and determine factors related to psychomotor development.<p ...

hrp0092p1-293 | Thyroid (1) | ESPE2019

Genetic Susceptibility to Hashimito's Thyroiditis in Children: Analysis of Polymorphisms rs7093069 – IL2RA, rs5742909 – CTLA 4, rs7138803 – FAIM2

Goralczyk Aleksandra

Background: Hashimito's Thyroiditis is influenced by genetic and environmental factors. Interleukin-2 receptor alpha chain (IL2RA) gene polymorphism and Cytotoxic T-lymphocyte antigen 4 (CTLA 4) gene polymorphism are known to be associated with HT, but have not been established in a Caucasian children population yet. The Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene polymorphisms impact on the development of HT in children has not been reported yet....

hrp0092p1-294 | Thyroid (1) | ESPE2019

Effect of serum TSH level on ovarian volume in prepubertal girls with subclinical hypothyroidism

Yigit Özgül , Sert Tugba , Ekinci Deniz , Kirankaya Aysegül , Kilinç Suna

Background and Objectives: Enlargement and cystic changes in ovaries of patients with longstanding overt hypothyroidism has been observed in numerous case reports. But there is limited data about the effect of subclinical hypothyroidism (SH) on ovarian volume and ovarian cyst formation. We evaluated the relationship between serum thyroid stimulating hormone (TSH) level and ovarian volume and sonographic appearance in prepubertal girls with SH.<p class="abs...

hrp0092p1-295 | Thyroid (1) | ESPE2019

The Natural History of Delayed TSH Elevation in Neonatal Intensive Care (NICU) Newborns

Zung Amnon , Radi Alin , Almashanu Shlomo

Context: Delayed TSH elevation (dTSH) is defined as elevated TSH in the second neonatal screen following normal TSH in the initial screen. The clinical outcome of newborns with dTSH is not entirely elucidated, although several studies have suggested a full recovery in most cases.Objective: We aim to elucidate the natural history of dTSH in a group of neonatal intensive care newborns. In addition, we aim to define clinica...