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58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

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The theme of this year’s meeting is Variety and Variation in Paediatric Endocrinology. Join us in Vienna to explore the diversity we encounter in our discipline and the care that we have to exercise when using the term “normality”. Whilst gaining an update on the latest treatments, clinical best practice and cutting edge research in the field of paediatric endocrinology.

Free Communications

Diabetes and Insulin Session 2

hrp0092fc7.1 | Diabetes and Insulin Session 2 | ESPE2019

Deployment of a Predictive Model Based on CpG Methylation Haplotypes Analysis on the Insulin Gene Promoter, in a Cohort of Children and Adolescents with Type 1 Diabetes

Kotanidou Eleni P , Mouzaki Konstantina , Chouvarda Ioanna , Koutsiana Elisavet , Kosvyra Alexandra , Giza Styliani , Galli-Tsinopoulou Assimina

Background: Cytosine-guanine(CpGs) sites in molecules identified as methylated or unmethylated; the combination of them in the genetic sequence of an individual includes a methylation haplotype (methyl-haplotype) for a specific locus. The insulin gene promoter(IGP) is highly regulated by methylation mechanisms, which lead to alteration of gene expression.Aim: To identify IGPmethyl-haplotypes among children/adolescents wi...

hrp0092fc7.2 | Diabetes and Insulin Session 2 | ESPE2019

Copeptin Kinetics and its Relationship to Osmolality During Rehydration for Diabetic Ketoacidosis in Children: An Observational Study

Burckhardt Marie-Anne , Beglinger Svetlana , Gotta Verena , Renggli Luzia , Bachmann Sara , Hess Melanie , Rentsch Katharina , Koch Gilbert , Zumsteg Urs , Jones Timothy , Pfister Marc , Szinnai Gabor

Background: Copeptin is a surrogate marker for arginine vasopressin (AVP) release in response to hyperosmolal stimuli such as diabetic ketoacidosis (DKA). We aimed to characterize the temporal course (kinetics) of serum osmolality and copeptin during rehydration and insulin therapy in children with type 1 diabetes (T1D) and DKA, and the relationship between both (dynamics).Methods: An observational multi-center study was...

hrp0092fc7.3 | Diabetes and Insulin Session 2 | ESPE2019

MicroRNA Circulating Levels in Children at Diagnosis of Type 1 Diabetes

Inzaghi Elena , Rapini Novella , Deodati Annalisa , Schiaffini Riccardo , Patera Patrizia , Matteoli Maria Cristina , Ciampalini Paolo , Cianfarani Stefano

Background: Type 1 diabetes (T1D) is a chronic disease characterized by autoimmune destruction of pancreatic beta-cells. Dysregulated miRNA levels have been described in T1D patients, though results are inconclusive.Objective and Hypotheses: The aim of this study was to assess the circulating profile of different miRNAs in children at diagnosis of T1D.Method: 27 children with T1D o...

hrp0092fc7.4 | Diabetes and Insulin Session 2 | ESPE2019

Metabolic Syndrome Features in Pre-Pubertal Children Born After Maternal Pre-Eclampsia

Goffin Sarah , Derraik José , Chiavaroli Valentina , Biggs Janene , Hofman Paul , Groom Katie , Cutfield Wayne

Background: Pre-eclampsia is associated with important complications for both mother and baby in the short term, but there are limited data about its long-term effects on offspring metabolism. Thus, we aimed to assess whether maternal pre-eclampsia was associated with adverse effects on metabolism and body composition in the offspring in childhood.Methods: We studied healthy pre-pubertal children (aged 4–10 years) b...

hrp0092fc7.5 | Diabetes and Insulin Session 2 | ESPE2019

Is the 1-hour Post-Load Glucose Level by 75g Oral Glucose Tolerance Test a New Risk Factor in Predicting Atherosclerosis?

Kilinç Suna , Demirtaş Tuna , Atay Zeynep

Background and Objectives: Recent studies demonstrated that a 1-hour post-load plasma glucose (1-h PG) value of ≥155 mg/dL during an oral glucose tolerance test (OGTT) is a new risk factor for predicting atherosclerosis. Herein, we evaluated whether individuals with normal glucose tolerance (NGT), whose 1-h PG is ≥155mg/dl, or with impaired glucose tolerance (IGT) have an increased carotid intima–media thickness (CIMT), as compared with NGT in...

hrp0092fc7.6 | Diabetes and Insulin Session 2 | ESPE2019

2017 American Academy of Pediatrics Clinical Practice Guideline: Impact on Prevalence of Arterial Hypertension in Children and Adolescents with Type 1 Diabetes mellitus

Dost Axel , Bechtold Susanne , Fink Katharina , Bonfig Walter , Wiemann Dagobert , Kapellen Thomas Michael , Witsch Michael , Schwab Karl Otfried , Holl Reinhard Walter

Background: In 2017 the American Academy of Pediatrics has introduced a new guideline (AAP 2017) to diagnose arterial hypertension in children, as the blood pressure thresholds for adults had been lowered before. There is a controversy about these new reference levels as other societies have not followed these recommendations. We studied the impact of the new AAP 2017 guideline on prevalence of arterial hypertension (HTN) in children with Type 1 diabetes melli...