Background: One of the speculated causes of the decreasing age of onset of type 1 diabetes is the increase in body weight in children. This so-called accelerator hypothesis is, however, controversial. The aim of the study was to test whether younger age of type 1 diabetes onset is associated with higher BMI-SDS at the time of diagnosis.
Methods: Retrospective data analysis from medical records of all patients under the age of 14 (n=559; 50.6% male), with newly diagnosed type 1 diabetes in Lesser Poland between 2006 and 2017.
Results: There were only 15 (2.7%) cases of obesity at the moment of diagnosis. An increase in BMI-SDS by 1 unit was associated with the development of the disease 0.54 years later. Interestingly, BMI-SDS was higher in the older age groups, during puberty.
Conclusion: The results of the present study do not confirm that younger age of type 1 diabetes onset is associated with higher BMI-SDS at the time of diagnosis, and therefore are insufficient to prove the accelerator hypothesis. However, the results point to a possible contribution of increased body weight during puberty on the age of type 1 diabetes manifestation. This concept requires further investigation.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology