ESPE Abstracts (2019) 92 P1-174

The Optimal Dosage of Vitamin D Supplement for Vitamin D deficiency in Korean Children and Adolescents

Seung Yang1, Kyung Hee Yi2, Eun Young Kim3, Il Tae Hwang1


1Hallym University College of Medicine, Seoul, Korea, Republic of. 2Wonkwang University Sanbon Medical Center, Gunpo, Korea, Republic of. 3Chosun University School of Medicine, Gwangju, Korea, Republic of


Purpose: Vitamin D deficiency (VDD) is very common nowadays in children as well as in adults, probably due to decreased exposure to sunlight. In Korea, the prevalence of VDD was 47% in teenage boys and 65% in teenage girls. However, the optimal dosage regimen for correcting deficiency is unknown. We investigate the change of serum 25(OH) vitamin D concentration according to the treatment dosage and duration in VDD.

Methods: Data was collected from 1797 children and adolescents aged 0 to 16 year between August in 2017 and July in 2018, retrospectively. They were divided to 3 groups (deficiency, insufficiency, sufficiency) according to their serum 25(OH) vitamin D concentrations (less than 20, between 20 and 30, more than 30 ng/mL, respectively). There were 3 subgroups (poor, moderate, good) according the daily increase (DI) of the serum 25(OH) vitamin D concentration (less than 0.3, between 0.3 and 0.6, more than 0.6 ng/mL/day, respectively) after 4 to 6 week oral administration of 25(OH) vitamin D in children and adolescents with vitamin D deficiency.

Results: The serum 25(OH) vitamin D concentration showed the correlation with age (P=0.000), gender (P=0.000), weight standard deviation score (SDS) (P=0.008) and body mass index (BMI) SDS (P=0.000). And the serum 25(OH) vitamin D concentration showed seasonal variation in children over 2 years of age and adolescents (P=0.000). There was a significant correlation between serum 25(OH) vitamin D concentration and DI (P=0.021). In VDD patients treated with vitamin D, DI were not correlated with age, sex, weight SDS and BMI SDS.

Conclusions: The prevalence of VDD increased in female, older age, overweight and winter in Korea and the response to treatment was higher in patient with lower serum 25(OH) D concentration. It may be appropriate to take an oral 25(OH) Vitamin D with 2000 IU/day for 6 weeks in Korean children and adolescents with VDD.

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