ESPE Abstracts (2019) 92 P1-38

The Factors Associated with High Levels of HbA1C in Children and Young People with Type 1 Diabetes Mellitus

Omolola Ayoola, Deborah Kendall


Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom


Introduction: Patients with diabetes are encouraged to achieve good glycaemic control to reduce the risks of complications. Many factors are associated with glycaemic control.

The objective of this study was to evaluate factors associated with good glycaemic control among a cohort of children and young people with type 1 diabetes in Lancashire United kingdom.

Methods: All children and young people with Type 1 diabetes being managed in the diabetic unit at Lancashire Teaching hospitals within the North West region of the United Kingdom were evaluated from April 2016 to March 2017. Patients were classified based on their HbA1C levels below 58 mmol/ mol (Low HbA1C) and above or equal to 58mmol/mol (High HA1C). Sociodemographic and clinical factors were correlated with HbA1C levels.

Results: There were 195 total patients aged 4 to 19 years (mean age, 14.4 years) and 43.6% were females. The mean HbA1C of the cohort was 71 mmol/mol (SD 18), and 80% of the patients had high HbA1C.

Factors independently correlated with increased HbA1c levels included duration of diabetes number of contacts with diabetic nurses and the use of continuous glucose monitoring system (CGMS) and free style libre. Significant factors associated with low HbA1C using univariate analyses included duration of diabetes with diagnosis duration less than 5 years (P=0.002) and use of continuous glucose monitoring system (CGMS) and free style libre (P=0.001).

Conclusions: Good glycaemic control was associated with diagnosis duration less than 5 years and and use of continuous glucose monitoring system (CGMS) and free style libre. Therefore, management of patients focusing on these associated factors would be of great benefit in improving glycaemic control.

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