ESPE Abstracts (2019) 92 P1-48

Waist Circumference Triglyceride Index is Useful to Predict Non-alcoholic Fatty Liver Disease in Childhood Obesity

Bahar Özcabi1, Salih Demirhan2, Özden Aksu3, Hatice Öztürkmen Akay4, Ayla Güven1


1HSU Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Division of Pediatric Endocrinology, Istanbul, Turkey. 2HSU Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey. 3HSU Haydarpasa Numune Training and Research Hospital, Department of Pedatrics, Istanbul, Turkey. 4HSU Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Department of Radiology, Istanbul, Turkey


Objectives: We aimed to evaluate the performance of waist circumference triglyceride index(WTI) to predict non-alcoholic fatty liver disease(NAFLD) in obese children.

Methods: In this study 139 obese children(71 girls) were included(6-18 years). Height, weight, body mass index(BMI), waist circumference(WC), puberty stage, blood pressure, and biochemical values were obtained from the medical records. SDS and percentiles were calculated. The WTI was calculated as WC(cm)x triglyceride concentration(mmol/L). The total cholesterol/HDL-cholesterol index(TC/HDL-C) was calculated. NAFLD was showed by ultrasound. The AUC and appropriate cutoff points for WTI were calculated by ROC analysis.

Results: Anthropometric measurements, biochemical values and indexes in patients with and without liver fat are summarized in the Table 1. The WTI showed a positive correlation with weight(rho=0.2;P=0,037), insulin (rho=0.45;P<0.001), HOMA-IR(rho=0.44;P<0.001), uric acid(rho=0.97;P<0.001), TC(rho=0.35;P=0.004), TC/HDL-C(rho=0.46;P<0.001) and triglyceride(rho=0.957;P<0.001). It was found that WTI values could be used to diagnose hepatosteatosis[AUC=0.65 (0,56-0,75);P=0.002]. Sensitivity and specificity values for WTI≥190.4 cases were found as 51% and 75%, respectively. The cut-off points for WTI were AUC=0.71;P=0.003 (sensitivity=53%, specificity=82%) in males and AUC=0.67;P=0.003 (sensitivity=57%, specificity=75%) in pubertal.

Conclusion: The WTI is a powerful and easy tool to predict NAFLD in childhood and is correlated with uric acid level. This is the first study assessing the accuracy of WTI in childhood obesity.

Table1:
NAFLD No(n=71) Yes(n=68)
VariableMean±SD
Median(IQR)
Mean±SD
Median(IQR)
p
Age,year10.7±0.5 11.8±0.50.001
Gender
 Girl(71)
44(31.7%)27(19.4%)0.011
 Boy(68)27(19.4%)41(29.5%)
WeightSDS2.49±0.193.05±0.170.009
BMI27.64(5.22)30.7 (4.82)<0.001
BMISDS2.51 (0.79)2.7 (0.7)0.007
BMI%99.4% (2.1)99.7 (0.8)0.004
WC,cm84.8±2.295.3±2.6<0.001
SystolicBP,mmHg(n=102)114(11)120(14)0.015
DiastolicBP,mmHg(n=102)71±272±20.028
Fasting glucose,mg/dl89±290±10,561
Insulin,uU/ml12.7(10.6)15.5(8.9)<0.001
HOMA-IR2.51(2.43)3.34(2)<0.001
ALT,IU/L16(9)25(17)<0.001
Uric acid,mg/dl(n=135)4.7±0.95.5±1.30.046
Cholesterol,mg/dl175±6.4178±4.70.33
Triglyceride,mg/dl96(62)119(61)0.046
HDL-C,mg/dl(n=138)45(15)47(14)0.272
LDL-C,mg/dl(n=134)105±5.7106±4.10.239
TC/HDL-C,(n=138)3.98(1.23)3.9(1.4)0.002
WTI165(75)198(109.7)<0.001

Article tools

My recent searches

No recent searches.