ESPE Abstracts (2019) 92 P1-75

Impact of -202 IGFBP-3 Promoter Polymorphism on Growth Responses in Korean Children with Idiopathic Short Stature

II Tae Hwang1, Kyung Hee Yi2, Eun Young Kim3, Seung Yang1


1Hallym University College of Medicine, Seoul, Korea, Republic of. 2Wonkwang University Sanbon Medical Center, Gunpo, Korea, Republic of. 3Chosun University School of Medicine, Gwangju, Korea, Republic of


Purpose: Our previous study showed no correlation between -202 A/C IGFBP-3 promoter polymorphism and Δheight SDS in children with growth hormone deficiency. We investigated the influences of the -202 IGFBP-3 polymorphism on 1-year follow-up outcomes of GH treatment in Korean children with ISS.

Methods: Data was obtained from 81 children with idiopathic short stature (peak serum growth hormone (GH) ≥ 7.0 ng/mL by GH stimulation test with 2 different stimulants). They were treated with GH for at least 1 year between 2014 and 2016. 69 of them were analyzed polymorphism of -202 IGFBP-3 promoter region (A or C). Their height velocity during GH treatment, serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) concentrations before and after GH treatment, respectively. Children with chronic disease, known syndromic disease and small for gestational age (SGA).

Results: Distribution of the -202 IGFBP-3 genotypes was as follows: AA genotype 69.6%; AC genotype 24.6%; and CC genotype 5.8%. Comparing the AA group with the AC and CC group, significant difference was observed in serum IGFBP-3 concentration at diagnosis (P=0.032) but no significant difference after the treatment (P=0.499). There were no statistically significant differences in ΔHeight, Δ IGF-1 level, and Δ IGFBP-3 level before and after GH treatment between two allele groups. No significant difference between C allele frequency and ΔHeight SDS was seen (P=0.935).

Conclusion: The results suggest that -202 IGFBP-3 promoter polymorphism may not be a major factor in GH treatment in Korean children with ISS.

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